Evidence map›Paper›PMID 27908782›Full record

ReviewFree radical biology & medicine2017

Adaptive responses of neuronal mitochondria to bioenergetic challenges: Roles in neuroplasticity and disease resistance.

Sophia M Raefsky, Mark P Mattson

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Free radical biology & medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
121citing papers in PubMed, 2 pooled it
14.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

121 citing papers in PubMed, 2 syntheses or guidelines pooled it, 261 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Norepinephrine regulates hippocampal mitochondrial biogenesis via β2-adrenergic receptor signaling and PGC-1α.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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61 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Sophia M RaefskyLaboratory of Neurosciences, National Institute on Aging, Baltimore, MD 21224, United States.
Mark P MattsonLaboratory of Neurosciences, National Institute on Aging, Baltimore, MD 21224, United States; Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States. Electronic address: mark.mattson@nih.gov.
National Institute on Aging · US

Funding

Intramural NIH HHS ZIA AG000312Intramural NIH HHS ZIA AG000314Intramural NIH HHS ZIA AG000315Intramural NIH HHS ZIA AG000317
6 · The paper itself

Abstract

An important concept in neurobiology is "neurons that fire together, wire together" which means that the formation and maintenance of synapses is promoted by activation of those synapses. Very similar to the effects of the stress of exercise on muscle cells, emerging findings suggest that neurons respond to activity by activating signaling pathways (e.g., Ca

Indexed as

Organelle BiogenesisDisease ResistanceDNA RepairEnergy MetabolismHumansMitochondriaNeurodegenerative DiseasesNeuronal PlasticityNeuronsSignal Transduction3-hydroxybutyrateAerobic exerciseAutophagyCREBHormesisIntermittent fastingMitochondrial biogenesisPGC-1α

Identifiers

PMID27908782
PMCPMC5209274
OpenAlexW2557816682

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.