ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2017
Associations between serum vitamin E concentration and bone mineral density in the US elderly population.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Effects of exercise on bone density and physical performance in postmenopausal women: A systematic review and meta-analysis.PM & R : the journal of injury, function, and rehabilitation · 2024Pooled it
- Tocotrienols Regulate Bone Loss through Suppression on Osteoclast Differentiation and Activity: A Systematic Review.Current drug targets · 2018Pooled it
- Sex-specific association of plasma vitamin E with homocysteine concentrations in Chinese middle-aged and older men and women: evidence from pooled population-based study.European journal of nutrition · 2026Article
- Effects of melatonin and vitamin E on bone healing following alloplastic grafting in osteoporotic cranial bone defects: an experimental study.BMC oral health · 2026Article
- The role of fat-soluble vitamins on bone metabolism and osteoporosis: a literature review.Annals of medicine · 2025Review
- Non-Linear Association of Relationship Between Serum Vitamin E and Eczema in US Adults.Food science & nutrition · 2025Article
- Association between dietary vitamin E intake and incident cardiovascular disease, cardiovascular, and all-cause mortality: A prospective cohort study using NHANES 2003-2018 data.International journal of cardiology. Cardiovascular risk and prevention · 2025Article
- Associations of comprehensive dietary antioxidant index with postmenopausal femur bone mineral density and osteoporosis: data from the national health and nutrition examination survey.Frontiers in nutrition · 2025Article
- Role of vitamins beyond vitamin DInternational journal of molecular medicine · 2024Review
- Elucidating causal relationships of diet-derived circulating antioxidants and the risk of osteoporosis: A Mendelian randomization study.Frontiers in genetics · 2024Article
- Association between dietary vitamin E and osteoporosis in older adults in the United States.Frontiers in endocrinology · 2024Article
- Association between dietary intake of α-tocopherol and cadmium related osteoporosis in population ≥ 50 years.Journal of bone and mineral metabolism · 2023Article
- Association between multiple vitamins and bone mineral density: a cross-sectional and population-based study in the NHANES from 2005 to 2006.BMC musculoskeletal disorders · 2023Article
- Article
- Vitamin E enriched diet increases the rate of orthodontic tooth movement.American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics · 2022Article
- Functional Food for Elderly High in Antioxidant and Chicken Eggshell Calcium to Reduce the Risk of Osteoporosis-A Narrative Review.Foods (Basel, Switzerland) · 2021Review
- Osteoclast Multinucleation: Review of Current Literature.International journal of molecular sciences · 2020Review
- Article
- Bone Mineral Density in Premenopausal Women Is Associated with the Dietary Intake of α-Tocopherol: A Cross-Sectional Study.Nutrients · 2019Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mixed findings regarding effects of vitamin E on bone metabolism existed. We were the first to find a negative association between serum α-tocopherol concentration and bone mineral density in the US elderly population. Using vitamin E supplement as α-tocopherol to promote bone health was not warranted at this time.
introductionThe aim of the study is to examine the associations between serum vitamin E (α-tocopherol and γ-tocopherol) status and bone mineral density (BMD) among the US elderly population.
methodsWe used data from the National Health and Nutrition Examination Survey (NHANES) 2005-2006. This cross-sectional study finally included 989 subjects who were not having liver diseases, kidney diseases, rheumatoid arthritis, or cancers; were not treated for osteoporosis; and were not taking steroids or female hormones. Multivariable linear regression models were employed to examine the associations between serum vitamin E (α-tocopherol and γ-tocopherol) concentration and BMDs of total spine and femoral neck after adjusting for covariates and potential confounders.
resultsSignificant differences in serum α-tocopherol and γ-tocopherol levels, dietary intake of vitamin E as α-tocopherol, and BMDs of total spine and femoral neck were presented between male and female participants. Serum α-tocopherol and γ-tocopherol concentrations were found to be inversely correlated (r = -0.169, P < 0.001). In univariable linear models, significant negative associations between serum α-tocopherol and both total spine BMD (β = -0.0014, P = 0.002) and femoral neck BMD (β = -0.0017, P < 0.001) were found. Accounting for covariates, serum α-tocopherol level was negatively associated with femoral neck BMD (β = -0.0007, P = 0.028).
conclusionsThis study found a negative association between serum α-tocopherol concentration and femoral neck BMD in the US elderly population, suggesting a harmful effect of α-tocopherol on bone health. Future studies are warranted to further examine the dose-response relationships between individual vitamin E isomers and bone metabolism.
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