SynthesisProceedings of the National Academy of Sciences of the United States of America2016
KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference.
Open access · bronzeAbstract readMeta-Analysis
In one paragraph
Synthesis in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 144 papers, 8 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
144citing papers in PubMed, 8 pooled it
17.8field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
144 citing papers in PubMed, 8 syntheses or guidelines pooled it, 247 citations in OpenAlex.
- Genetic architecture of alcohol consumption identified by a genotype-stratified GWAS and impact on esophageal cancer risk in Japanese people.Science advances · 2024Pooled it
- Self-management with alcohol over lifespan: psychological mechanisms, neurobiological underpinnings, and risk assessment.Molecular psychiatry · 2023Pooled it
- Genome-wide meta-analysis of alcohol use disorder in East Asians.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Pooled it
- New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders.Nature human behaviour · 2019Pooled it
- Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use.Biological psychiatry · 2019Pooled it
- Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use.Nature genetics · 2019Pooled it
- Genome-Wide Association Study Meta-Analysis of the Alcohol Use Disorders Identification Test (AUDIT) in Two Population-Based Cohorts.The American journal of psychiatry · 2019Pooled it
- Meta-Analysis of Genetic Influences on Initial Alcohol Sensitivity.Alcoholism, clinical and experimental research · 2018Pooled it
- Antibody-mediated activation of the FGFR1/Klothoβ complex corrects metabolic dysfunction and alters food preference in obese humans.Proceedings of the National Academy of Sciences of the United States of America · 2020Trial
- The Hormone FGF21 Stimulates Water Drinking in Response to Ketogenic Diet and Alcohol.Cell metabolism · 2018Trial
- Protein Decoys, Alcohol, and Energy Intake: Testing a Mechanistic-Ecological Model.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Review
- Mendelianization: Concentrating Polygenic Signal Into a Single Causal Locus.Genetic epidemiology · 2026Article
- Regulatory mechanisms driven by functional 3'-UTR variants in alcohol use disorder and related traits.Genome biology · 2026Article
- A loss-of-function variant in GFRAL associates with increased alcohol consumption in humans.bioRxiv : the preprint server for biology · 2026Article
- Article
- Single-cell Multiome Analysis of Chromatin State and Transcriptome in the Human Basal Ganglia.bioRxiv : the preprint server for biology · 2026Article
- The causal interplay between depression and alcohol use from adolescence to young adulthood: a Mendelian randomization study.Psychological medicine · 2026Article
- Negative feedback regulation of alcohol ingestion through the FGF21-PVH oxytocin-VTA dopamine system.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Association Between Educational Attainment and the Risk of Gynecological Malignancies: A Mediation Mendelian Randomization Study.International journal of women's health · 2026Article
- Salient cue reactivity and eating behaviors in ex-smokers, abstinent alcohol use disorder, and obesity.Frontiers in psychiatry · 2026Article
84 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
127 authors at 20 institutions in 17 countries.
Gunter SchumannMedical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF, United Kingdom; gunter.schumann@kcl.ac.uk davo.mango@utsouthwestern.edu p.elliott@imperial.ac.uk.
Chunyu LiuThe Framingham Heart Study, Framingham, MA 01702.
Paul O'ReillyMedical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF, United Kingdom.
He GaoDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom.
Parkyong SongDepartment of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Bing XuMedical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF, United Kingdom.
Barbara RuggeriMedical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF, United Kingdom.
Najaf AminGenetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.
Tianye JiaMedical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF, United Kingdom.
Sarah PreisDepartment of Biostatistics, Boston University School of Public Health, Boston, MA 02118.
Marcelo Segura LepeDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom.
Shizuo AkiraLaboratory of Host Defense, World Premier International Immunology Frontier Research Center, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan.
Caterina BarbieriDivision of Genetics and Cell Biology, San Raffaele Research Institute, 20132 Milan, Italy.
Sebastian BaumeisterInstitute for Community Medicine, University Medicine Greifswald, Greifswald 17475, Germany.
Stephane CauchiCNRS UMR 8199, Lille Pasteur Institute, European Genomic Institute for Diabetes, Lille 2 University, 59000 Lille, France.
Toni-Kim ClarkeDivison of Psychiatry, University of Edinburgh, Edinburgh EH10 5HF, United Kingdom.
Stefan EnrothScience for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, 75108 Uppsala, Sweden.
Krista FischerEstonian Genome Center, University of Tartu, 51010 Tartu, Estonia.
Jenni HällforsInstitute for Molecular Medicine, University of Helsinki, 00290 Helsinki, Finland.
Sarah E HarrisCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, United Kingdom.
Saskia HieberDepartment of Psychiatry and Psychotherapy, Friedrich Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany.
Edith HoferClinical Division of Neurogeriatrics, Department of Neurology, Medical University Graz, 8036 Graz, Austria.
Jouke-Jan HottengaDepartment of Biological Psychology, Vrije Universiteit Amsterdam and EMGO Institute for Health and Care Research, 1081 BT Amsterdam, The Netherlands.
Åsa JohanssonScience for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, 75108 Uppsala, Sweden.
Peter K JoshiUsher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, United Kingdom.
Niina KaartinenNational Institute for Health and Welfare, 00271 Helsinki, Finland.
Jaana LaitinenQuantified Employee-Unit, Finnish Institute of Occupational Health, 00250 Helsinki, Finland.
Rozenn LemaitreCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101.
Anu LoukolaInstitute for Molecular Medicine, University of Helsinki, 00290 Helsinki, Finland.
Jian'an LuanMedical Research Council Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, United Kingdom.
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry, Fimlab Laboratories and University of Tampere School of Medicine, Tampere 33520, Finland.
Massimo ManginoDepartment of Twin Research and Genetic Epidemiology, King's College, London SE1 7EH, United Kingdom.
Ani ManichaikulCenter for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA 22903.
Hamdi MbarekDepartment of Biological Psychology, Vrije Universiteit Amsterdam and EMGO Institute for Health and Care Research, 1081 BT Amsterdam, The Netherlands.
Yuri MilaneschiDepartment of Psychiatry, Institute for Health and Care Research (EMGO) Institute for Health and Care Research and Neuroscience Campus Amsterdam, Vrije Universiteit Amsterdam University Medical Center/Geestelijke Gezondheids Zorg (GGZ) inGeest, 1081 HL Amsterdam, The Netherlands.
Alireza MoayyeriDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom.
Kenneth MukamalDepartment of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215.
Christopher NelsonDepartment of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester LE3 9QP, United Kingdom.
Jennifer NettletonDivision of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas Health Sciences Center, Houston, TX 77225.
Eemil PartinenFaculty of Medicine, University of Tartu, 50411 Tartu, Estonia.
Rajesh RawalDepartment of Molecular Epidemiology, Institute of Epidemiology II, Helmholtz Zentrum München, 85764 Neuherberg, Germany.
Antonietta RobinoInstitute for Maternal and Child Health-Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Burlo Garofolo, 34137 Trieste, Italy.
Lynda RoseDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215.
Cinzia SalaDivision of Genetics and Cell Biology, San Raffaele Research Institute, 20132 Milan, Italy.
Takashi SatohLaboratory of Host Defense, World Premier International Immunology Frontier Research Center, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan.
Reinhold SchmidtClinical Division of Neurogeriatrics, Department of Neurology, Medical University Graz, 8036 Graz, Austria.
Katharina SchrautUsher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, United Kingdom.
Robert ScottMedical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, United Kingdom.
Albert Vernon SmithResearch Institute, Icelandic Heart Association, 201 Kopavogur, Iceland.
John M StarrCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, United Kingdom.
Alexander TeumerInstitute for Community Medicine, University Medicine Greifswald, Greifswald 17475, Germany.
Stella TrompetDepartment of Cardiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
André G UitterlindenDepartment of internal Medicine, Erasmus Medical Center, 3015 CN Rotterdam, The Netherlands.
Cristina VenturiniDepartment of Twin Research and Genetic Epidemiology, King's College, London SE1 7EH, United Kingdom.
Anne-Claire VergnaudDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom.
Niek VerweijDepartment of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands.
Veronique VitartMedical Research Council Human Genetics Unit, Institute for Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, United Kingdom.
Dragana VuckovicDepartment of Medical Sciences, University of Trieste, 34149 Trieste, Italy.
Juho WedenojaDepartment of Public Health, University of Helsinki, 00014 Helsinki, Finland.
Loic YengoCNRS UMR 8199, Lille Pasteur Institute, European Genomic Institute for Diabetes, Lille 2 University, 59000 Lille, France.
Bing YuHuman Genetics Center, University of Texas Health Science Center at Houston, Houston, TX 77225.
Weihua ZhangDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom.
Jing Hua ZhaoMedical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, United Kingdom.
Dorret I BoomsmaDepartment of Biological Psychology, Vrije Universiteit Amsterdam and EMGO Institute for Health and Care Research, 1081 BT Amsterdam, The Netherlands.
John ChambersDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom.
Daniel I ChasmanDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215.
Toniolo DanielaDivision of Genetics and Cell Biology, San Raffaele Research Institute, 20132 Milan, Italy.
Eco de GeusDepartment of Biological Psychology, Vrije Universiteit Amsterdam and EMGO Institute for Health and Care Research, 1081 BT Amsterdam, The Netherlands.
Ian DearyCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, United Kingdom.
Johan G ErikssonNational Institute for Health and Welfare, 00271 Helsinki, Finland.
Tõnu EskoEstonian Genome Center, University of Tartu, 51010 Tartu, Estonia.
Volker EulenburgInstitute for Biochemistry and Molecular Medicine, Friedrich Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany.
Oscar H FrancoDepartment of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.
Philippe FroguelCNRS UMR 8199, Lille Pasteur Institute, European Genomic Institute for Diabetes, Lille 2 University, 59000 Lille, France.
Christian GiegerDepartment of Molecular Epidemiology, Institute of Epidemiology II, Helmholtz Zentrum München, 85764 Neuherberg, Germany.
Hans J GrabeDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, 17475 Greifswald, Germany.
Vilmundur GudnasonResearch Institute, Icelandic Heart Association, 201 Kopavogur, Iceland.
Ulf GyllenstenScience for Life Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, 75108 Uppsala, Sweden.
Tamara B HarrisNational Institute on Aging, NIH, Bethesda, MD 20892.
Anna-Liisa HartikainenDepartment of Obstetrics and Gynecology, Oulu University Hospital, 90029 Oulu, Finland.
Andrew C HeathDepartment of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, MO 63110.
Lynne HockingInstitute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, United Kingdom.
Albert HofmanDepartment of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.
Cornelia HuthInstitute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, D-85764 Neuherberg, Germany.
Marjo-Riitta JarvelinDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom.
J Wouter JukemaDepartment of Cardiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
Jaakko KaprioInstitute for Molecular Medicine, University of Helsinki, 00290 Helsinki, Finland.
Jaspal S KoonerDepartment of Cardiology, Ealing Hospital, Middlesex UB1 3HW, United Kingdom.
Zoltan KutalikInstitute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudoise, 1010 Lausanne, Switzerland.
Jari LahtiFolkhälsan Research Centre, Public Health Research, 00290 Helsinki, Finland.
Claudia LangenbergMedical Research Council Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, United Kingdom.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories and University of Tampere School of Medicine, Tampere 33520, Finland.
Yongmei LiuWake Forest School of Medicine, Department of Epidemiology & Prevention, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157.
Pamela A F MaddenDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110.
Nicholas MartinGenetic Epidemiology, Queensland Institute of Medical Research Berghofer Medical Research Institute, Herston, Brisbane QLD 4029, Australia.
Alanna MorrisonHuman Genetics Center, University of Texas Health Science Center at Houston, Houston, TX 77225.
Brenda PenninxDepartment of Psychiatry, Institute for Health and Care Research (EMGO) Institute for Health and Care Research and Neuroscience Campus Amsterdam, Vrije Universiteit Amsterdam University Medical Center/Geestelijke Gezondheids Zorg (GGZ) inGeest, 1081 HL Amsterdam, The Netherlands.
Nicola PirastuUsher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, United Kingdom.
Bruce PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101.
Olli RaitakariDepartment of Clinical Physiology and Nuclear Medicine, Turku University Hospital, University of Turku, Turku 20520, Finland.
Paul RidkerDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215.
Richard RoseDepartment of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405.
Jerome I RotterInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles Medical Center, Torrance, CA 90509.
Nilesh J SamaniDepartment of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester LE3 9QP, United Kingdom.
Helena SchmidtInstitute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, 8010 Graz, Austria.
Tim D SpectorDepartment of Twin Research and Genetic Epidemiology, King's College, London SE1 7EH, United Kingdom.
David StottInstitute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow G31 2ER, United Kingdom.
David StrachanPopulation Health Research Institute, St. George's, University of London, London SW17 0RE, United Kingdom.
Ioanna TzoulakiDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom.
Pim van der HarstDepartment of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands.
Cornelia M van DuijnGenetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.
Pedro Marques-VidalDepartment of Medicine, Internal Medicine, Lausanne University Hospital, 1011 Lausanne, Switzerland.
Peter VollenweiderDepartment of Medicine, Internal Medicine, Lausanne University Hospital, 1011 Lausanne, Switzerland.
Nicholas J WarehamMedical Research Council Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge CB2 0QQ, United Kingdom.
John B WhitfieldGenetic Epidemiology, Queensland Institute of Medical Research Berghofer Medical Research Institute, Herston, Brisbane QLD 4029, Australia.
James WilsonUsher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, United Kingdom.
Bruce WolffenbuttelDepartment of Endocrinology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands.
Georgy BakalkinDivision of Biological Research on Drug Dependence, Department of Pharmaceutical, Biosciences, Uppsala University, 751 24 Uppsala, Sweden.
Evangelos EvangelouDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom.
Yun LiuKey Laboratory of Metabolism and Molecular Medicine, Ministry of Education, 200032 Shanghai, People's Republic of China.
Kenneth M RiceDepartment of Biostatistics, University of Washington, Seattle, WA 98195.
Sylvane DesrivièresMedical Research Council-Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF, United Kingdom.
Steven A KliewerDepartment of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
David J MangelsdorfDepartment of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390; gunter.schumann@kcl.ac.uk davo.mango@utsouthwestern.edu p.elliott@imperial.ac.uk.ORCID 0000-0002-4355-0796
Christian P MüllerDepartment of Psychiatry and Psychotherapy, Friedrich Alexander University Erlangen-Nuremberg, 91054 Erlangen, Germany.
Daniel LevyThe Framingham Heart Study, Framingham, MA 01702.
Paul ElliottDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, United Kingdom; gunter.schumann@kcl.ac.uk davo.mango@utsouthwestern.edu p.elliott@imperial.ac.uk.
University of Cambridge · GBKing's College London · GBUniversity of Helsinki · FIUppsala University · SEBrigham and Women's Hospital · USCentre National de la Recherche Scientifique · FRFriedrich-Alexander-Universität Erlangen-Nürnberg · DEMedical University of Graz · ATUniversity Medical Center Groningen · NLAmsterdam Public Health · NLBoston University · USCentre for Global Health Research · CAHoward Hughes Medical Institute · USMinistry of Education of the People's Republic of China · CNNational Health Service · GBOsaka International University · JPQIMR Berghofer Medical Research Institute · AUSan Raffaele University of Rome · ITUniversitätsmedizin Greifswald · DEUniversity of Edinburgh · GB
Funding
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILES Frome WILKINSON · 2003 to 2026
$40.4MCHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MRare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9MCHS research resources for the cardiovascular health of older adultsU01HL130114 · NHLBI · UNIVERSITY OF WASHINGTON · PI BURKE, GREGORY L, KRONMAL, RICHARD A · 2016 to 2019
$6.6MThe Women's Health Study: Infrastructure Support for Continued Cohort Follow-upUM1CA182913 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 2014 to 2018
$4.0MGenetic analysis of AGES-Reykjavik Study and the Health ABCZIAAG006000 · NIA · NATIONAL INSTITUTE ON AGING · PI HARRIS, TAMARA · 2009 to 2017
$1.3MAdolescent Alcohol Abuse: A Twin-Study PerspectiveR01AA012502 · NIAAA · TRUSTEES OF INDIANA UNIVERSITY · PI ROSE, RICHARD JOSEPH · 2013 to 2017
$1.2MChief Scientist Office CZD/16/6/4Medical Research Council MC_PC_U127561128Medical Research Council MC_UU_12015/1Medical Research Council MR/K026992/1Medical Research Council MR/L01341X/1Medical Research Council MR/L01632X/1Medical Research Council MR/N015746/1NCATS NIH HHS UL1 TR000124NCI NIH HHS UM1 CA182913NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL120393NHLBI NIH HHS U01 HL130114NIAAA NIH HHS R01 AA012502NIDDK NIH HHS P30 DK063491
Abstract
Excessive alcohol consumption is a major public health problem worldwide. Although drinking habits are known to be inherited, few genes have been identified that are robustly linked to alcohol drinking. We conducted a genome-wide association metaanalysis and replication study among >105,000 individuals of European ancestry and identified β-Klotho (KLB) as a locus associated with alcohol consumption (rs11940694; P = 9.2 × 10
Indexed as
Alcohol DrinkingAnimalsBehavior, AnimalBrainEmotionsFemaleFibroblast Growth FactorsGenome-Wide Association StudyHumansKlotho ProteinsLiverMaleMembrane ProteinsMiceMice, 129 StrainMice, Inbred C57BLfibroblast growth factor 21Fibroblast Growth FactorsKLB protein, humanKlb protein, mouseKlotho ProteinsMembrane Proteinsalcohol consumptionFGF21humanmouse modelβ-Klotho
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.