Evidence map›Paper›PMID 27913872›Full record

Trial reportEuropean journal of nutrition2017

Treatment for 6 months with fish oil-derived n-3 polyunsaturated fatty acids has neutral effects on glycemic control but improves dyslipidemia in type 2 diabetic patients with abdominal obesity: a randomized, double-blind, placebo-controlled trial.

Feng Wang, Yanyan Wang, Yan Zhu, Xiaosong Liu, Hui Xia, Xian Yang, Guiju Sun

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 3 pooled it
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 56 citations in OpenAlex.

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  19. Effect ofMetabolites · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Feng WangKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, China.
Yanyan WangKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, China.
Yan ZhuFood Nutrition and Safety Society in Yixing, Yixing, China.
Xiaosong LiuGuanlin Hospital in Yixing, Yixing, China.
Hui XiaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, China.
Xian YangKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, China.
Guiju SunKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, China. gjsun@seu.edu.cn.
Southeast University · CNJiangsu University · CN

Funding

National Natural Science Foundation of China 81573144the Fundamental Research Funds for the Central Universities, and the Graduate Research and Innovation Projects of Colleges in Jiangsu Province KYLX15_0175the nutrition research foundation from the Chinese Nutrition Society 201326
6 · The paper itself

Abstract

purposeThis study aimed to determine the effects of fish oil-derived n-3 PUFA on glycemic control and lipid profiles in type 2 diabetic patients with abdominal obesity.

methodsIn a randomized, double-blind, placebo-controlled trial, 100 type 2 diabetic patients with abdominal obesity were randomized into two groups including 4 g/day of fish oil (2.4 g n-3 PUFA) or placebo (corn oil) for 6 months. Serum fatty acid, body composition, as well as markers of glucose regulation and lipid parameters were measured before and after intervention.

resultsThirty-five men and 64 women aged 65.4 ± 5.3 years completed the intervention. Although body composition was unchanged, serum EPA and DHA were higher in the fish oil group than those in the placebo group (P < 0.001 and P < 0.001, respectively). Serum triglyceride (TG) decreased (P = 0.007), whereas high-density lipoprotein cholesterol (HDL-C) increased (P = 0.006) in the fish oil group compared with the placebo group after 6 months. Serum total cholesterol, low-density lipoprotein cholesterol (LDL-C), the ratio of LDL-C to HDL-C, and glycemic control (measured by serum glucose, glycated hemoglobin, insulin, and homeostasis model assessment-insulin resistance) were not significantly different between the two groups after 6 months.

conclusionsThis study showed that 6 months of fish oil supplement had no statistically significant effects on glycemic control, but improved TG and HDL-C in type 2 diabetic patients with abdominal obesity.

trial registrationChictr.org ChiCTR-TRC-14005084.

Indexed as

AgedBlood GlucoseBody CompositionCholesterolCorn OilDiabetes Mellitus, Type 2Docosahexaenoic AcidsDouble-Blind MethodDyslipidemiasEicosapentaenoic AcidFemaleFish OilsGlycated HemoglobinHumansMaleMiddle AgedBlood GlucoseCholesterolCorn OilDocosahexaenoic AcidsEicosapentaenoic AcidFish OilsGlycated HemoglobinTriglyceridesAbdominal obesityFish oilGlycemic controlLipid levelsn-3 polyunsaturated fatty acidsType 2 diabetes

Identifiers

PMID27913872
OpenAlexW2557372219

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.