Statins × lipids

TrialLipids2017

L-Carnitine/Simvastatin Reduces Lipoprotein (a) Levels Compared with Simvastatin Monotherapy: A Randomized Double-Blind Placebo-Controlled Study.

M Florentin et al.PubMed ↗Publisher ↗

  • L-carnitine 2 g/day plus simvastatin 20 mg/daylooks good hereLower lp levels, no range given.No ranges given.

What the trial testedas reported · 58 people · 2017

No range given

Reported lower lp levels, no range given

−19.4percentage points

L-carnitine 2 g/day plus simvastatin 20 mg/day vs placebo plus simvastatin 20 mg/day

As reported

difference −19.4 %, no interval

+1 more in the walkthrough ↓

Who was studied, and how

58people with dyslipidemia, in this paper

The trial randomly assignedassigned by chance

L-carnitine 2 g/day plus simvastatin 20 mg/day
placebo plus simvastatin 20 mg/day

Reported lower lp levels, no range given−19.4

randomised

the abstract, start to end

in the L-carnitine/simvastatin group [-19.4%, from 52 (20-171) to 42 (15-102) mg/dL; p = 0.01], but not in the placebo/simvastatin group [-6.7%, from 56 (26-108) to 52

← favours treatmentfavours comparator →
could be chance
No interval given · direction only, strength unknown
Lp(a) levelsL-carnitine 2 g/day plus simvastatin 20 mg/day vs placebo plus simvastatin 20 mg/day
−19.4
Lp(a) levelsplacebo plus simvastatin 20 mg/day
−6.7
StatinsSupplements & botanicalsLipids

Statins × lipidshelps?mixed

unlikelylikely
0.500.50 without it

Supplements & botanicals × lipidshelps?one trial

unlikelylikely
0.50only evidence
← favours treatmentfavours comparator →
this papermore certainless certain
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6 papers cite it

2017
2018
2019
2020
2021
2022
2023
2024
this paperpooled itcites it
Full record →Abstract, authors, funding and every citing paper · PMID 27914033