Evidence map›Paper›PMID 27916613›Full record

ReviewCytokine2017

Leptin in inflammation and autoimmunity.

Antonio La Cava

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cytokine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 195 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
195citing papers in PubMed, 4 pooled it
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

195 citing papers in PubMed, 4 syntheses or guidelines pooled it, 333 citations in OpenAlex.

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135 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Antonio La CavaDepartment of Medicine, University of California Los Angeles, 1000 Veteran Ave. 32-59, Los Angeles, CA 90095, United States. Electronic address: alacava@mednet.ucla.edu.
University of California, Los Angeles · US

Funding

Leptin and mTOR: metabolic partners in autoimmunityR21AI109677 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LA CAVA, ANTONIO · 2015 to 2016
$424k
NIAID NIH HHS R21 AI109677
6 · The paper itself

Abstract

After its discovery as a key controller of metabolic function, leptin has been later extensively implicated in additional functions including important modulatory activities on the innate and adaptive immune response. This review analyzes the known implications of leptin in multiple inflammatory conditions, including autoimmune diseases, and how this knowledge could be instrumental in the design of leptin-based manipulation strategies to help restoration of abnormal immune responses.

Indexed as

AutoimmunityAdaptive ImmunityAnimalsHumansImmunity, InnateInflammationLeptinMiceObesityLeptinAutoimmunityInflammationLeptin

Identifiers

PMID27916613
PMCPMC5453851
OpenAlexW2563743072

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.