Evidence map›Paper›PMID 27938461›Full record

SynthesisPublic health nutrition2017

Effect of fortified milk on growth and nutritional status in young children: a systematic review and meta-analysis.

Misa Matsuyama, Tracy Harb, Michael David, Peter Sw Davies, Rebecca J Hill

Open access · bronzeAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Public health nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 11 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 11 syntheses or guidelines pooled it, 36 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Misa Matsuyama1Children's Nutrition Research Centre,Child Health Research Centre,The University of Queensland,Level 6,Centre for Children's Health Research,63 Graham Street,South Brisbane,QLD 4101,Australia.
Tracy Harb1Children's Nutrition Research Centre,Child Health Research Centre,The University of Queensland,Level 6,Centre for Children's Health Research,63 Graham Street,South Brisbane,QLD 4101,Australia.
Michael David2School of Public Health,The University of Queensland,Herston,QLD,Australia.
Peter Sw Davies1Children's Nutrition Research Centre,Child Health Research Centre,The University of Queensland,Level 6,Centre for Children's Health Research,63 Graham Street,South Brisbane,QLD 4101,Australia.
Rebecca J Hill1Children's Nutrition Research Centre,Child Health Research Centre,The University of Queensland,Level 6,Centre for Children's Health Research,63 Graham Street,South Brisbane,QLD 4101,Australia.
University of Queensland · AUChildren's Medical Research Institute · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveAdequate nutrition is critical for optimal growth and development. However, young children may be at risk of nutrient deficiencies when transitioning to weaning foods for a variety of reasons. Supplementation with fortified milk may provide potentially lacking essential nutrients, but effects on growth and nutritional status are yet to be established.

designFive databases were searched for randomised controlled trials using fortified milk against control milk in young children. Outcomes were growth, body composition and/or biochemical markers. Pooled differences in means were calculated for continuous outcomes and odds ratios for binary outcomes.

settingRandomised controlled trials set in any country. SUBJECTS: Otherwise healthy children aged 6-47 months.

resultsFifteen articles met the eligibility criteria. Fortification varied from Fe, Zn, vitamins, essential fatty acids, to pre- and/or probiotics. Frequently reported outcomes were weight, height and Fe status. Studies varied in geographical location, sample size and duration. Fortified milk had minimal effects on weight gain (mean difference=0·17 kg; 95 % CI 0·02, 0·31 kg) compared with control milk. The risk of anaemia was reduced in fortified milk groups (OR=0·32; 95 % CI 0·15, 0·66) compared with control groups. There were no significant effects on height gain, changes in body composition or Hb concentration.

conclusionsFortified milk is an effective source of complementary nutrition to supplement children in need when consumed in appropriate amounts in addition to a normal diet. Due to compositional differences, further research on fortified milk is warranted before making global recommendations on benefits for growth and nutritional outcomes in young children.

Indexed as

Child DevelopmentFood, FortifiedNutritional StatusAnemia, Iron-DeficiencyAnimalsBiomarkersBody CompositionBody WeightChild, PreschoolHumansInfantMicronutrientsMilkRandomized Controlled Trials as TopicRisk FactorsSensitivity and SpecificityBiomarkersMicronutrientsFortified milkGrowthIron deficiencyNutritional statusYoung children

Identifiers

PMID27938461
PMCPMC10261583
OpenAlexW2565897586

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.