Evidence map›Paper›PMID 27978504›Full record

ArticleRedox biology2017

Redox-guided axonal regrowth requires cyclic GMP dependent protein kinase 1: Implication for neuropathic pain.

Lucie Valek, Annett Häussler, Stefan Dröse, Philipp Eaton, Katrin Schröder, Irmgard Tegeder

Open access · goldAbstract read
In one paragraph

Article in Redox biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. NADPH Oxidases in Pain Processing.Antioxidants (Basel, Switzerland) · 2022
    Review
  8. Article
  9. Article
  10. In Vivo Imaging with Genetically Encoded Redox Biosensors.International journal of molecular sciences · 2020
    Review
  11. Mast cell tetrahydrobiopterin contributes to itch in mice.Journal of cellular and molecular medicine · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Lucie ValekDepts. of Clinical Pharmacology, Goethe-University Hospital, Frankfurt, Germany.
Annett HäusslerDepts. of Clinical Pharmacology, Goethe-University Hospital, Frankfurt, Germany.
Stefan DröseDepts. of Anaesthesiology, Goethe-University Hospital, Frankfurt, Germany.
Philipp EatonKing's College of London, Cardiovascular Division, The Rayne Institute, St. Thomas' Hospital, London, United Kingdom.
Katrin SchröderDepts. of Cardiovascular Physiology, Goethe-University Hospital, Frankfurt, Germany.
Irmgard TegederDepts. of Clinical Pharmacology, Goethe-University Hospital, Frankfurt, Germany. Electronic address: itegeder@hotmail.com.
University Hospital Frankfurt · DEGoethe University Frankfurt · DESt Thomas' Hospital · GB

Funding

NORMAL, THALASSEMIC AND LEUKEMIC GENE EXPRESSIONK04HL001098 · NHLBI · YALE UNIVERSITY · PI BENZ, EDWARD J · 1985 to 1986
–
IONIC CONTROL OF CARDIAC MUSCLE CONTRACTION: E-C COUPLIK04HL001526 · NHLBI · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI BERS, DONALD M · 1985 to 1989
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NHLBI CLINICAL INVESTIGATOR AWARD PROGRAMK08HL001145 · NHLBI · UNIVERSITY OF CHICAGO · PI BARRON, WILLIAM M · 1985 to 1987
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ARACHIDONATE METABOLISM IN GLOMERULONEPHRITIS/VASCULITISK08HL001313 · NHLBI · WASHINGTON UNIVERSITY · PI LEFKOWITH, JAMES B · 1985 to 1988
–
Biotechnology and Biological Sciences Research Council BB/C503646/1British Heart Foundation FS/11/45/28859British Heart Foundation PG/10/98/28655British Heart Foundation PG/13/13/30018British Heart Foundation PG/15/26/31373British Heart Foundation RG/12/12/29872Medical Research Council G0600785Medical Research Council G0700320Medical Research Council G1000458Medical Research Council MR/K003232/1Medical Research Council MR/L009684/1
6 · The paper itself

Abstract

Cyclic GMP-dependent protein kinase 1 (PKG1) mediates presynaptic nociceptive long-term potentiation (LTP) in the spinal cord and contributes to inflammatory pain in rodents but the present study revealed opposite effects in the context of neuropathic pain. We used a set of loss-of-function models for in vivo and in vitro studies to address this controversy: peripheral neuron specific deletion (SNS-PKG1

Indexed as

AnimalsAxonsCyclic GMPCyclic GMP-Dependent Protein Kinase Type IHumansHyperalgesiaLong-Term PotentiationMiceNeuralgiaNeuronsOxidation-ReductionSignal TransductionCyclic GMPCyclic GMP-Dependent Protein Kinase Type ICofilinGrowth coneNerve regenerationPainRedoxSensory neuronSignaling ROS

Identifiers

PMID27978504
PMCPMC5156608
OpenAlexW2560750264

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.