ArticleJournal of applied physiology (Bethesda, Md. : 1985)2017
Changes in muscle fiber contractility and extracellular matrix production during skeletal muscle hypertrophy.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 53 citations in OpenAlex.
- Mechanical loading induces the longitudinal growth of muscle fibers via a rapamycin-insensitive mechanism.Science advances · 2026Article
- Paraspinal muscle fibres demonstrate a complex relationship between contractile variability and function in canines with spinal degeneration.Scientific reports · 2025Article
- Role of pulmonary rehabilitation in extracellular matrix protein expression in vastus lateralis muscle in atrophic and nonatrophic patients with COPD.ERJ open research · 2025Article
- The Structural Adaptations That Mediate Mechanical Load-Induced Changes in Muscle Mass.Advances in experimental medicine and biology · 2025Review
- The utility-and limitations-of the rodent synergist ablation model in examining mechanisms of skeletal muscle hypertrophy.American journal of physiology. Cell physiology · 2024Review
- Cyclin D3 Colocalizes with Myogenin and p21 in Skeletal Muscle Satellite Cells during Early-Stage Functional Overload.Acta histochemica et cytochemica · 2023Article
- Alignment, cross linking, and beyond: a collagen architect's guide to the skeletal muscle extracellular matrix.American journal of physiology. Cell physiology · 2023Review
- Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions.Physiological reviews · 2023Review
- Overload in a Rat In Vivo Model of Synergist Ablation Induces Tendon Multiscale Structural and Functional Degeneration.Journal of biomechanical engineering · 2023Article
- A glitch in the matrix: the pivotal role for extracellular matrix remodeling during muscle hypertrophy.American journal of physiology. Cell physiology · 2022Review
- Senolytic treatment rescues blunted muscle hypertrophy in old mice.GeroScience · 2022Article
- Myotendinous Junction: Exercise Protocols Can Positively Influence Their Development in Rats.Biomedicines · 2022Article
- CCN2 participates in overload-induced skeletal muscle hypertrophy.Matrix biology : journal of the International Society for Matrix Biology · 2022Article
- Shoulder Lesions Do Not Increase Inflammatory Biomarkers in Patients Undergoing Surgery for Glenohumeral Instability: An Exploratory Study.Translational sports medicine · 2022Article
- Evidence of myomiR regulation of the pentose phosphate pathway during mechanical load-induced hypertrophy.Physiological reports · 2021Article
- Maternal protein restriction changes structural and metabolic gene expression in the skeletal muscle of aging offspring rats.Histology and histopathology · 2021Article
- Article
- Nucleus Type-Specific DNA Methylomics Reveals Epigenetic "Memory" of Prior Adaptation in Skeletal Muscle.Function (Oxford, England) · 2021Article
- Satellite Cell Depletion Disrupts Transcriptional Coordination and Muscle Adaptation to Exercise.Function (Oxford, England) · 2021Article
- Accounting for Material Changes in Decellularized Tissue with Underutilized Methodologies.BioMed research international · 2021Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Skeletal muscle can adapt to increased mechanical loads by undergoing hypertrophy. Transient reductions in whole muscle force production have been reported during the onset of hypertrophy, but contractile changes in individual muscle fibers have not been previously studied. Additionally, the extracellular matrix (ECM) stores and transmits forces from muscle fibers to tendons and bones, and determining how the ECM changes during hypertrophy is important in understanding the adaptation of muscle tissue to mechanical loading. Using the synergist ablation model, we sought to measure changes in muscle fiber contractility, collagen content, and cross-linking, and in the expression of several genes and activation of signaling proteins that regulate critical components of myogenesis and ECM synthesis and remodeling during muscle hypertrophy. Tissues were harvested 3, 7, and 28 days after induction of hypertrophy, and nonoverloaded rats served as controls. Muscle fiber specific force (sF
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.