Evidence map›Paper›PMID 27986587›Full record

ArticleSurgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery2017

The utility of weight loss medications after bariatric surgery for weight regain or inadequate weight loss: A multi-center study.

Fatima Cody Stanford, Nasreen Alfaris, Gricelda Gomez, Elizabeth T Ricks, Alpana P Shukla, Kathleen E Corey, Janey S Pratt, Alfons Pomp, Francesco Rubino, Louis J Aronne

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 8 pooled it
13.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 8 syntheses or guidelines pooled it, 205 citations in OpenAlex.

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  6. Guideline
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  11. Beyond surgery: a multimodal framework for a pediatric metabolic and bariatric surgery program in a safety-net children's hospital.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2026
    Article
  12. Review
  13. Impact of preoperative and postoperative anti-obesity medications on early postoperative body mass index reduction after sleeve gastrectomy in pediatrics.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2026
    Article
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24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Fatima Cody StanfordMGH Weight Center, Gastrointestinal Unit-Department of Medicine, Massachusetts General Hospital, Boston, MA; Endocrine Unit, Department of Pediatrics, Massachusetts General Hospital, Boston, MA; Harvard Medical School, Boston, MA. Electronic address: fstanford@mgh.harvard.edu.
Nasreen AlfarisMGH Weight Center, Gastrointestinal Unit-Department of Medicine, Massachusetts General Hospital, Boston, MA; Harvard Medical School, Boston, MA; Obesity, Metabolism and Nutrition Institute, Massachusetts General Hospital, Boston, MA.
Gricelda GomezHarvard Medical School, Boston, MA; Harvard T.H. Chan School of Public Health, Boston, MA.
Elizabeth T RicksComprehensive Weight Control Center, Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Weill Cornell Medical College, New York, NY; Institute of Human Nutrition, Columbia University, New York, NY; Texas Tech University- Paul L. Foster School of Medicine, El Paso, TX.
Alpana P ShuklaComprehensive Weight Control Center, Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Weill Cornell Medical College, New York, NY.
Kathleen E CoreyHarvard Medical School, Boston, MA; Gastrointestinal Unit-Department of Medicine, Massachusetts General Hospital, Boston, MA.
Janey S PrattHarvard Medical School, Boston, MA; Department of Surgery, Massachusetts General Hospital, Boston, MA.
Alfons PompDepartment of GI Metabolic and Bariatric Surgery, Weill Cornell Medical College, New York, NY.
Francesco RubinoDepartment of Metabolic and Bariatric Surgery, Kings College London and Kings College Hospital, London, UK.
Louis J AronneInstitute of Human Nutrition, Columbia University, New York, NY.
Cornell University · USHarvard University · USMassachusetts General Hospital · USColumbia University · USKing's College London · GB

Funding

Bone Metabolism in Adolescents Undergoing Bariatric SurgeryR01DK103946 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BREDELLA, MIRIAM ANTOINETTE, MISRA, MADHUSMITA · 2015 to 2019
$3.2M
NIDDK NIH HHS R01 DK103946
6 · The paper itself

Abstract

backgroundPatients who undergo bariatric surgery often have inadequate weight loss or weight regain.

objectivesWe sought to discern the utility of weight loss pharmacotherapy as an adjunct to bariatric surgery in patients with inadequate weight loss or weight regain.

settingTwo academic medical centers.

methodsWe completed a retrospective study to identify patients who had undergone bariatric surgery in the form of a Roux-en-Y gastric bypass (RYGB) or a sleeve gastrectomy from 2000-2014. From this cohort, we identified patients who were placed on weight loss pharmacotherapy postoperatively for inadequate weight loss or weight regain. We extracted key demographic data, medical history, and examined weight loss in response to surgery and after the initiation of weight loss pharmacotherapy.

resultsA total of 319 patients (RYGB = 258; sleeve gastrectomy = 61) met inclusion criteria for analysis. More than half (54%; n = 172) of all study patients lost≥5% (7.2 to 195.2 lbs) of their total weight with medications after surgery. There were several high responders with 30.3% of patients (n = 96) and 15% (n = 49) losing≥10% (16.7 to 195.2 lbs) and≥15% (25 to 195.2 lbs) of their total weight, respectively, Topiramate was the only medication that demonstrated a statistically significant response for weight loss with patients being twice as likely to lose at least 10% of their weight when placed on this medication (odds ratio = 1.9; P = .018). Regardless of the postoperative body mass index, patients who underwent RYGB were significantly more likely to lose≥5% of their total weight with the aid of weight loss medications.

conclusionsWeight loss pharmacotherapy serves as a useful adjunct to bariatric surgery in patients with inadequate weight loss or weight regain.

Indexed as

Bariatric SurgeryAdultAgedAnti-Obesity AgentsBody Mass IndexCombined Modality TherapyFemaleGastrectomyGastric BypassHealthy LifestyleHumansMaleMiddle AgedMultiple Chronic ConditionsObesity, MorbidPostoperative CareAnti-Obesity AgentsBariatric surgeryInadequate weight lossObesityObesity co-morbiditiesWeight regain

Identifiers

PMID27986587
PMCPMC6114136
OpenAlexW2546249836

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.