Evidence map›Paper›PMID 27995094›Full record

ReviewFrontiers in cellular and infection microbiology2016

The Cytolethal Distending Toxin Contributes to Microbial Virulence and Disease Pathogenesis by Acting As a Tri-Perditious Toxin.

Monika D Scuron, Kathleen Boesze-Battaglia, Mensur Dlakić, Bruce J Shenker

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in cellular and infection microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 91 citations in OpenAlex.

  1. Cytolethal distending toxin enhancesInfection and immunity · 2026
    Article
  2. Integrated study on the occurrence and genomic features ofApplied and environmental microbiology · 2026
    Article
  3. Cytolethal Distending Toxin EnhancesbioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
  6. Wild raccoons (Microbiology spectrum · 2025
    Article
  7. Article
  8. Genomic characterization of multidrug-resistantFrontiers in microbiology · 2025
    Article
  9. In Vitro Antibacterial Activity of Essential Oils fromPathogens (Basel, Switzerland) · 2024
    Article
  10. Article
  11. Antimicrobial Resistance and Pathotypes ofAnimals : an open access journal from MDPI · 2024
    Article
  12. Article
  13. Microorganisms · 2024
    Review
  14. The microbial landscape of colorectal cancer.Nature reviews. Microbiology · 2024
    Review
  15. Microbiology spectrum · 2024
    Article
  16. Pathogens (Basel, Switzerland) · 2024
    Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Monika D ScuronDepartment of Pathology, School of Dental Medicine, University of Pennsylvania Philadelphia, PA, USA.
Kathleen Boesze-BattagliaDepartment of Biochemistry, School of Dental Medicine, University of Pennsylvania Philadelphia, PA, USA.
Mensur DlakićDepartment of Microbiology and Immunology, Montana State University Bozeman, MT, USA.
Bruce J ShenkerDepartment of Pathology, School of Dental Medicine, University of Pennsylvania Philadelphia, PA, USA.
University of Pennsylvania · USMontana State University · US

Funding

BACTERIA &LYMPHOCYTE SUPPRESSION IN PERIODONTITISR01DE006014 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI SHENKER, BRUCE J · 1985 to 2021
$8.6M
A. Actinomycetemcomitans Cdt Induces Pro-Inflammatory Innate Immune ResponsesR01DE023071 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI BOESZE-BATTAGLIA, KATHLEEN, SHENKER, BRUCE J · 2013 to 2024
$4.6M
Lysosomal maturation during periodontal infectionsR01DE022465 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI BOESZE-BATTAGLIA, KATHLEEN · 2012 to 2016
$2.0M
NIDCR NIH HHS R01 DE006014NIDCR NIH HHS R01 DE022465NIDCR NIH HHS R01 DE023071
6 · The paper itself

Abstract

This review summarizes the current status and recent advances in our understanding of the role that the cytolethal distending toxin (Cdt) plays as a virulence factor in promoting disease by toxin-producing pathogens. A major focus of this review is on the relationship between structure and function of the individual subunits that comprise the AB

Indexed as

Bacterial InfectionsBacterial ToxinsPhosphatidylinositol 3-KinaseProtein BindingProtein SubunitsSignal TransductionVirulence FactorsBacterial Toxinscytolethal distending toxinPhosphatidylinositol 3-KinaseProtein SubunitsVirulence Factorsepithelial cellsinflammationlymphocytesmacrophagesPI-3 kinasetoxinvirulence

Identifiers

PMID27995094
PMCPMC5136569
OpenAlexW2558584423

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.