Evidence map›Paper›PMID 27995278›Full record

ArticlePsychopharmacology2017

Modulation of PKA, PKC, CAMKII, ERK 1/2 pathways is involved in the acute antidepressant-like effect of (octylseleno)-xylofuranoside (OSX) in mice.

Lucimar M Pinto Brod, Mariana G Fronza, Jaqueline Pinto Vargas, Diogo S Lüdtke, César Augusto Brüning, Lucielli Savegnago

Abstract read
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In one paragraph

Article in Psychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Lucimar M Pinto BrodPrograma de Pós Graduação em Biotecnologia, PPGBiotec, Grupo de Pesquisa em Neurobiotecnologia - GPN, CDTec, Universidade Federal de Pelotas, UFPel, Pelotas, RS, Brazil.
Mariana G FronzaPrograma de Pós Graduação em Biotecnologia, PPGBiotec, Grupo de Pesquisa em Neurobiotecnologia - GPN, CDTec, Universidade Federal de Pelotas, UFPel, Pelotas, RS, Brazil.
Jaqueline Pinto VargasInstituto de Química, Universidade Federal do Rio Grande do Sul, UFRGS, Av. Bento Gonçalves 9500, Porto Alegre, RS, 91501-970, Brazil.
Diogo S LüdtkeInstituto de Química, Universidade Federal do Rio Grande do Sul, UFRGS, Av. Bento Gonçalves 9500, Porto Alegre, RS, 91501-970, Brazil.
César Augusto BrüningNúcleo de Síntese, Aplicação e Análise de Compostos Orgânicos e Inorgânicos, Universidade Federal da Fronteira Sul, Cerro Largo, RS, Brazil.
Lucielli SavegnagoPrograma de Pós Graduação em Biotecnologia, PPGBiotec, Grupo de Pesquisa em Neurobiotecnologia - GPN, CDTec, Universidade Federal de Pelotas, UFPel, Pelotas, RS, Brazil. luciellisavegnago@yahoo.com.br.
Universidade Federal de Pelotas · BRUniversidade Federal do Rio Grande do Sul · BRUniversidade Federal da Fronteira Sul · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationale(Octylseleno)-xylofuranoside (OSX) is an organoselenium compound from the class of alkylseleno carbohydrates possessing a C8 alkyl chain. Members of this class of organoselenium compounds have promising pharmacological activities, among them are antioxidant and acute antidepressant-like activities with the involvement of monoaminergic system, as previously presented by our research group.

objectiveThe objective of the study was to investigate the possible involvement of cellular signalling pathways in the antidepressant-like effect caused by OSX (0.01 mg/kg, oral route (p.o.) by gavage) in the tail suspension test (TST) in mice.

methodsMice were treated by intracerebroventricular (i.c.v.) injection either with vehicle or with H-89 (1 μg/site i.c.v., an inhibitor of protein kinase A-PKA), KN-62 (1 μg/site i.c.v., an inhibitor of Ca

resultsThe antidepressant-like effect of orally administered OSX was blocked by treatment of the mice with H-89, KN-62, chelerythrine and PD098059; all inhibitors of signalling proteins involved with neurotrophic signalling pathways. The number of crossings in the OFT was not altered by treatment with OSX and/or signalling antagonists.

conclusionsThe results demonstrated that OSX showed an antidepressant-like effect in the TST in mice through the activation of protein kinases PKA, PKC, CAMKII and ERK1/2 that are involved in intracellular signalling pathways.

Indexed as

1-(5-Isoquinolinesulfonyl)-2-MethylpiperazineAnimalsAntidepressive AgentsCalcium-Calmodulin-Dependent Protein Kinase Type 2Cyclic AMP-Dependent Protein KinasesGlycosidesHindlimb SuspensionIsoquinolinesMaleMAP Kinase Signaling SystemMiceOrganoselenium CompoundsProtein Kinase CSignal TransductionSulfonamides1-(5-Isoquinolinesulfonyl)-2-MethylpiperazineAntidepressive AgentsCalcium-Calmodulin-Dependent Protein Kinase Type 2Cyclic AMP-Dependent Protein KinasesGlycosidesIsoquinolinesKN 62N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide(octylseleno)-xylofuranosideOrganoselenium CompoundsProtein Kinase CSulfonamidesAntidepressant activityDepression signalling pathwaysOrganoselenium compoundsTail suspension test

Identifiers

PMID27995278
OpenAlexW2563491049

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.