Evidence map›Paper›PMID 28003374›Full record

Trial reportThe journals of gerontology. Series A, Biological sciences and medical sciences2017

Effects of Calorie Restriction in Obese Older Adults: The CROSSROADS Randomized Controlled Trial.

Jamy D Ard, Barbara Gower, Gary Hunter, Christine S Ritchie, David L Roth, Amy Goss, Brooks C Wingo, Eric V Bodner, Cynthia J Brown, David Bryan and 6 more

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The journals of gerontology. Series A, Biological sciences and medical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05804019 (Interventions Focusing on Nutrition and Physical Activities for Overweight and Obese Older Adults in Nursing Homes "IFEBO"), which is not on this map. Cited by 32 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 6 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05804019 nacompletednot on this mapstarted 2023, after this paper: background citation

Interventions Focusing on Nutrition and Physical Activities for Overweight and Obese Older Adults in Nursing Homes "IFEBO"

TypeinterventionalSponsorUniversity College AbsalonRan2023 to 2024Enrolled93ConditionsOverweight, Obesity and Other HyperalimentationArmsNutritional and physical interventions
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 6 syntheses or guidelines pooled it, 63 citations in OpenAlex.

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  5. Long-term effects of weight-reducing diets in people with hypertension.The Cochrane database of systematic reviews · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 1 country.

Jamy D ArdDepartment of Epidemiology and Prevention, Wake Forest University School of Medicine, Winston-Salem, North Carolina.
Barbara GowerDepartment of Nutrition Sciences, University of Alabama at Birmingham.
Gary HunterDepartment of Nutrition Sciences, University of Alabama at Birmingham.
Christine S RitchieDivision of Geriatrics, Department of Medicine, University of California, San Francisco.
David L RothDivision of Geriatric Medicine and Gerontology, Johns Hopkins University, Baltimore, Maryland.
Amy GossDepartment of Nutrition Sciences, University of Alabama at Birmingham.
Brooks C WingoDepartment of Occupational Therapy, University of Alabama at Birmingham.
Eric V BodnerDivision of Gerontology, Geriatrics, and Palliative Care, University of Alabama at Birmingham.
Cynthia J BrownDivision of Gerontology, Geriatrics, and Palliative Care, University of Alabama at Birmingham.
David BryanDepartment of Nutrition Sciences, University of Alabama at Birmingham.
David R BuysDepartment of Food Science, Nutrition, and Health Promotion, Mississippi State University, Starkville.
Marilyn C HaasDivision of Gerontology, Geriatrics, and Palliative Care, University of Alabama at Birmingham.
Akilah Dulin KeitaInstitute for Community Health Promotion, Brown University, Providence, Rhode Island.
Lee Anne FlaggDepartment of Sociology, University of Alabama at Birmingham.
Courtney P WilliamsDivision of Gerontology, Geriatrics, and Palliative Care, University of Alabama at Birmingham.
Julie L LocherDivision of Gerontology, Geriatrics, and Palliative Care, University of Alabama at Birmingham.
University of Alabama at Birmingham · USInstitute for Community Health · USJohns Hopkins University · USMississippi State University · USUniversity of California, San Francisco · USWake Forest University · US

Funding

UAB Nutrition Obesity Research Center (NORC)P30DK056336 · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2000 to 2025
$6.0M
UAB Diabetes Research CenterP30DK079626 · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2025 to 2025
$1.3M
UAB Obesity Training ProgramT32DK062710 · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2004 to 2025
$774k
UAB Pre-Doctoral Training Program in Obesity-Related ResearchT32HL105349 · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2025 to 2025
$418k
NHLBI NIH HHS T32 HL105349NIA NIH HHS K07 AG043588NIA NIH HHS R01 AG033094NIDDK NIH HHS P30 DK056336NIDDK NIH HHS P30 DK079626NIDDK NIH HHS T32 DK062710
6 · The paper itself

Abstract

backgroundWe lack a comprehensive assessment of the risks and benefits of calorie restriction in older adults at high risk for cardiometabolic disease. Calorie restriction may reduce visceral adipose tissue (VAT) but also have negative effects on lean mass and quality of life.

methodsWe conducted a 52-week, randomized controlled trial involving 164 older adults with obesity taking at least one medication for hyperlipidemia, hypertension, or diabetes. Interventions included an exercise intervention alone (Exercise), or with diet modification and body weight maintenance (Maintenance), or with diet modification and energy restriction (Weight Loss). The primary outcome was change in VAT at 12 months. Secondary outcomes included cardiometabolic risk factors, functional status, and quality of life.

resultsA total of 148 participants had measured weight at 12 months. Despite loss of -1.6% ± 0.3% body fat and 4.1% ± 0.7% initial body weight, Weight Loss did not have statistically greater loss of VAT (-192.6 ± 185.2 cm3) or lean mass (-0.4 ± 0.3 kg) compared with Exercise (VAT = -21.9 ± 173.7 cm3; lean mass = 0.3 ± 0.3 kg). Quality of life improved in all groups with no differences between groups. No significant changes in physical function were observed. Weight Loss had significantly greater improvements in blood glucose (-8.3 ± 3.6 mg/dL, p < .05) and HDL-cholesterol (5.3 ± 1.9, p < .01) compared with Exercise. There were no group differences in the frequency of adverse events.

conclusionsWhile moderate calorie restriction did not significantly decrease VAT in older adults at high risk for cardiometabolic disease, it did reduce total body fat and cardiometabolic risk factors without significantly more adverse events and lean mass loss.

Indexed as

Quality of LifeAgedBody Mass IndexCaloric RestrictionFemaleFollow-Up StudiesHumansMaleObesityRetrospective StudiesRisk FactorsTime FactorsTreatment OutcomeWeight Losscardiometabolic riskphysical functionquality of lifevisceral adipose tissueWeight reduction

Identifiers

PMID28003374
PMCPMC5861948
OpenAlexW2563319203

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.