Evidence map›Paper›PMID 28008134›Full record

ArticleThe Biochemical journal2017

Interacting post-muscarinic receptor signaling pathways potentiate matrix metalloproteinase-1 expression and invasion of human colon cancer cells.

Anan H Said, Shien Hu, Ameer Abutaleb, Tonya Watkins, Kunrong Cheng, Ahmed Chahdi, Panjamurthy Kuppusamy, Neeraj Saxena, Guofeng Xie, Jean-Pierre Raufman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Biochemical journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
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  5. Guanine nucleotide exchange factors and colon neoplasia.Frontiers in cell and developmental biology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Anan H SaidDivision of Gastroenterology and Hepatology, Department of Medicine, University of Maryland School of Medicine, 22 South Greene Street, N3W62, Baltimore, MD 21201-1595, U.S.A.
Shien HuDivision of Gastroenterology and Hepatology, Department of Medicine, University of Maryland School of Medicine, 22 South Greene Street, N3W62, Baltimore, MD 21201-1595, U.S.A.
Ameer AbutalebDivision of Gastroenterology and Hepatology, Department of Medicine, University of Maryland School of Medicine, 22 South Greene Street, N3W62, Baltimore, MD 21201-1595, U.S.A.
Tonya WatkinsDivision of Gastroenterology and Hepatology, Department of Medicine, University of Maryland School of Medicine, 22 South Greene Street, N3W62, Baltimore, MD 21201-1595, U.S.A.
Kunrong ChengDivision of Gastroenterology and Hepatology, Department of Medicine, University of Maryland School of Medicine, 22 South Greene Street, N3W62, Baltimore, MD 21201-1595, U.S.A.
Ahmed ChahdiDivision of Gastroenterology and Hepatology, Department of Medicine, University of Maryland School of Medicine, 22 South Greene Street, N3W62, Baltimore, MD 21201-1595, U.S.A.
Panjamurthy KuppusamyDivision of Gastroenterology and Hepatology, Department of Medicine, University of Maryland School of Medicine, 22 South Greene Street, N3W62, Baltimore, MD 21201-1595, U.S.A.
Neeraj SaxenaDivision of Gastroenterology and Hepatology, Department of Medicine, University of Maryland School of Medicine, 22 South Greene Street, N3W62, Baltimore, MD 21201-1595, U.S.A.
Guofeng XieDivision of Gastroenterology and Hepatology, Department of Medicine, University of Maryland School of Medicine, 22 South Greene Street, N3W62, Baltimore, MD 21201-1595, U.S.A.
Jean-Pierre RaufmanDivision of Gastroenterology and Hepatology, Department of Medicine, University of Maryland School of Medicine, 22 South Greene Street, N3W62, Baltimore, MD 21201-1595, U.S.A.
University of Maryland, Baltimore · US

Funding

Research Training in Gastroenterology and HepatologyT32DK067872 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI RAUFMAN, JEAN-PIERRE · 2005 to 2024
$7.2M
Creating a toolkit to measure in vivo bile acid transportR21DK093406 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI POLLI, JAMES E, RAUFMAN, JEAN-PIERRE · 2012 to 2013
$404k
M3R, MMP1 and Colon Cancer DisseminationI01BX002129 · VA · BALTIMORE VA MEDICAL CENTER · PI RAUFMAN, JEAN-PIERRE · 2015 to 2018
–
Transcriptional Repression of MMP7 by FXR in Intestinal Epithelial CellsI01BX002777 · VA · BALTIMORE VA MEDICAL CENTER · PI XIE, GUOFENG · 2016 to 2020
–
BLRD VA I01 BX002129BLRD VA I01 BX002777NIDDK NIH HHS R21 DK093406NIDDK NIH HHS T32 DK067872
6 · The paper itself

Abstract

M3 muscarinic receptor (M3R) expression is increased in colon cancer; M3R activation stimulates colon cancer cell invasion via cross-talk with epidermal growth factor receptors (EGFR), post-EGFR activation of mitogen-activated protein kinase (MAPK) extracellular signal-related kinase 1/2 (ERK1/2), and induction of matrix metalloproteinase-1 (

Indexed as

Gene Expression Regulation, NeoplasticAcetylcholineCaco-2 CellsCell Line, TumorEpidermal Growth FactorErbB ReceptorsHT29 CellsHumansMatrix Metalloproteinase 1Mitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3p38 Mitogen-Activated Protein KinasesPhosphorylationProtein Kinase C-alphaProtein Kinase InhibitorsReceptor, Muscarinic M3AcetylcholineEGFR protein, humanEpidermal Growth FactorErbB ReceptorsMAPK1 protein, humanMatrix Metalloproteinase 1Mitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3MMP1 protein, humanp38 Mitogen-Activated Protein KinasesProtein Kinase C-alphaProtein Kinase InhibitorsReceptor, Muscarinic M3RNA, Small Interferingsrc-Family KinasesTetradecanoylphorbol Acetatecell invasioncell signalingcolorectal cancermatrix metalloproteinasesmuscarinic receptorsp38 MAPK

Identifiers

PMID28008134
PMCPMC5650067
OpenAlexW2567608096

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.