ReviewInternational journal of molecular sciences2016
Metabolic Adaptation in Obesity and Type II Diabetes: Myokines, Adipokines and Hepatokines.
Review in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04528693 (The Effect of 12-week Circuit Training), which is not on this map. Cited by 78 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of 12-week Circuit Training (Combination of Strength and Endurance Exercises) on Insulin Sensitivity and Vascular Endothelial Function in Women With Insulin Resistance
Who cites it
78 citing papers in PubMed, 2 syntheses or guidelines pooled it, 211 citations in OpenAlex.
- Effects of plaza dancing on body composition and cardiopulmonary function in middle-aged and the aged healthy women: a systematic review and meta-analysis.Frontiers in public health · 2025Pooled it
- Effects of exercise training on Fetuin-a in obese, type 2 diabetes and cardiovascular disease in adults and elderly: a systematic review and Meta-analysis.Lipids in health and disease · 2019Pooled it
- Hepatokines modulation in obesity: which exercise training model is better in men with obesity?Frontiers in endocrinology · 2025Trial
- A Randomized Controlled Trial to Determine the Impact of Resistance Training versus Aerobic Training on the Management of FGF-21 and Related Physiological Variables in Obese Men with Type 2 Diabetes Mellitus.Journal of sports science & medicine · 2024Trial
- The impact of mild hypoxia exposure on myokine secretion in human obesity.International journal of obesity (2005) · 2023Trial
- Fetuin-B, a potential link of liver-adipose tissue cross talk during diet-induced weight loss-weight maintenance.Nutrition & diabetes · 2021Trial
- Rational Design of a Functional Fatty Acid Component for Alleviating Western Diet-Induced Insulin Resistance and Glycolipid Metabolism Disorders.Foods (Basel, Switzerland) · 2026Article
- Eight Weeks of Aerobic Exercise Training Improves Fitness, Metabolic Health, Inflammation, and Intestinal Barrier Integrity in Overweight and Obese Women of Different Age Groups.Life (Basel, Switzerland) · 2025Article
- Supplementation with Probiotic Camel Milk Powder Improves Serum Glucose and Cholesterol as Well as the Related Cytokines in Patients with Type 2 Diabetes Mellitus.Foods (Basel, Switzerland) · 2025Article
- Exercise training enhances myokine release and reduces brain insulin resistance: insights into muscle-CNS metabolic cross-talk.Metabolic brain disease · 2025Review
- Magnetic resonance imaging derived biomarkers for the diagnosis of type 2 diabetes with insulin resistance: A pilot study.World journal of diabetes · 2025Article
- Hand Osteoarthritis: Molecular Mechanisms, Randomized Controlled Trials, and the Future of Targeted Treatment.International journal of molecular sciences · 2025Review
- Article
- Caffeine-augmented Sprint interval training outcomes in obese women: an examination by inter-individual analysis on physical and physiological adaptive responses.Frontiers in nutrition · 2025Article
- Association between weight and body composition changes with falls risk in the Malaysian Elders Longitudinal Research (MELoR) study.BMJ open · 2024Article
- Chemerin in the Spotlight: Revealing Its Multifaceted Role in Acute Myocardial Infarction.Biomedicines · 2024Review
- Organ crosstalk and dysfunction in sepsis.Annals of intensive care · 2024Review
- Adipokines in the Crosstalk between Adipose Tissues and Other Organs: Implications in Cardiometabolic Diseases.Biomedicines · 2024Review
- Review
- Myokines Produced by Cultured Bovine Satellite Cells Harvested from 3- and 11-Month-Old Angus Steers.Animals : an open access journal from MDPI · 2024Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity and type II diabetes are characterized by insulin resistance in peripheral tissues. A high caloric intake combined with a sedentary lifestyle is the leading cause of these conditions. Whole-body insulin resistance and its improvement are the result of the combined actions of each insulin-sensitive organ. Among the fundamental molecular mechanisms by which each organ is able to communicate and engage in cross-talk are cytokines or peptides which stem from secretory organs. Recently, it was reported that several cytokines or peptides are secreted from muscle (myokines), adipose tissue (adipokines) and liver (hepatokines) in response to certain nutrition and/or physical activity conditions. Cytokines exert autocrine, paracrine or endocrine effects for the maintenance of energy homeostasis. The present review is focused on the relationship and cross-talk amongst muscle, adipose tissue and the liver as secretory organs in metabolic diseases.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.