Evidence map›Paper›PMID 28026044›Full record

ArticleClinical cardiology2017

Expression of programmed cell death-1 and its ligand B7 homolog 1 in peripheral blood lymphocytes from patients with peripartum cardiomyopathy.

Guozhi Xia, Xiaopu Zheng, Xinye Yao, Xiaowei Yao, Zhongwei Liu, Junkui Wang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical cardiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Guozhi XiaDepartment of Cardiovascular Medicine, First Affiliated Hospital, Medical College, Xi'an Jiaotong University, Xi'an, China.
Xiaopu ZhengDepartment of Cardiovascular Medicine, First Affiliated Hospital, Medical College, Xi'an Jiaotong University, Xi'an, China.
Xinye YaoDepartment of Cardiovascular Medicine, First Affiliated Hospital, Medical College, Xi'an Jiaotong University, Xi'an, China.
Xiaowei YaoDepartment of Cardiovascular Medicine, Shaanxi Provincial People's Hospital, Xi'an, China.
Zhongwei LiuDepartment of Cardiovascular Medicine, Shaanxi Provincial People's Hospital, Xi'an, China.
Junkui WangDepartment of Cardiovascular Medicine, Shaanxi Provincial People's Hospital, Xi'an, China.
First Affiliated Hospital of Xi'an Jiaotong University · CNShaanxi Provincial People's Hospital · CNShanxi Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundImmune response has been postulated to play a prominent role in the pathogenesis of peripartum cardiomyopathy (PPCM). Given the importance of programmed death (PD)-1 and its ligand B7 homologue 1 (B7-H1) costimulatory molecules as an immune regulatory pathway, this study aimed to investigate the effect of PD-1 and B7-H1 expression on immune response in peripheral blood lymphocytes from the patients with PPCM. HYPOTHESIS: PD-1 and B7-H1 may be involved in modulating immune response in PPCM.

methodsPeripheral blood lymphocytes were obtained from PPCM and pregnancy-matched healthy women. PD-1 and B7-H1 expression were determined using fluorescence quantitative reverse transcription-polymerase chain reactions (RT-PCR) and Western blot. The presence of serum interferon (IFN)-γ and interleukin (IL)-4 were determined with enzyme-linked immunosorbent assay.

resultsThe levels of pro-brain natriuretic peptide and IFN-γ were markedly elevated, whereas the levels of left ventricular ejection fraction and IL-4 were significantly reduced in PPCM patients compared to controls. Additionally, both RT-PCR and Western blot revealed that the levels of PD-1 and B7-H1 expression were decreased significantly in PPCM patients compared with controls. A significant positive correlation was observed between PD-1 and B7-H1 expression. Furthermore, PD-1 and B7-H1 expression showed significant negative correlation with IFN-γ, as well as positive correlation with IL-4. Therefore, decreased expression of PD-1 and B7-H1 led to a dysregulating immune response such that cellular immunity linked to T helper (Th)1 cells was predominant over humoral immunity linked to Th2 cells in PPCM.

conclusionsThis study provided the first findings that PD-1 and B7-H1 expression were decreased, which might impair functional regulation of negative costimulation on immune response that may work in the etiopathogenesis of PPCM.

Indexed as

AdolescentAdultB7-H1 AntigenCardiomyopathiesCase-Control StudiesFemaleHumansImmunity, CellularImmunity, HumoralInterferon-gammaInterleukin-4Natriuretic Peptide, BrainPeripartum PeriodPregnancyPregnancy Complications, CardiovascularProgrammed Cell Death 1 ReceptorB7-H1 AntigenCD274 protein, humanIFNG protein, humanIL4 protein, humanInterferon-gammaInterleukin-4Natriuretic Peptide, BrainPDCD1 protein, humanProgrammed Cell Death 1 ReceptorB7-H1CardiomyopathyCostimulationImmunePD-1Peripartum

Identifiers

PMID28026044
PMCPMC6490546
OpenAlexW2561659979

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.