Evidence map›Paper›PMID 28032353›Full record

ReviewAllergy2017

AllergoOncology - the impact of allergy in oncology: EAACI position paper.

E Jensen-Jarolim, H J Bax, R Bianchini, M Capron, C Corrigan, M Castells, D Dombrowicz, T R Daniels-Wells, J Fazekas, E Fiebiger and 22 more

Open access · hybridAbstract readReviewConsensus Statement
In one paragraph

Review in Allergy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 1 pooled it
9.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. AllergoOncology in Review: Harnessing Allergy in the Field of Oncology to Improve Patient Outcomes.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026
    Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. High malignancy rate in IgE-deficient children.International journal of cancer · 2025
    Observational
  13. Article
  14. Review
  15. Article
  16. The Association between Allergy and Cancer: A Case-Control Study.Asian Pacific journal of cancer prevention : APJCP · 2024
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors at 16 institutions in 12 countries.

E Jensen-JarolimThe Interuniversity Messerli Research Institute, University of Veterinary Medicine Vienna, Medical University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0003-4019-5765
H J BaxDivision of Genetics & Molecular Medicine, Faculty of Life Sciences and Medicine, St. John's Institute of Dermatology, King's College London, London, UK.
R BianchiniThe Interuniversity Messerli Research Institute, University of Veterinary Medicine Vienna, Medical University of Vienna, Vienna, Austria.
M CapronLIRIC-Unité Mixte de Recherche 995 INSERM, Université de Lille 2, CHRU de Lille, Lille, France.
C CorriganDivision of Asthma, Allergy and Lung Biology, Medical Research Council and Asthma UK Centre in Allergic Mechanisms in Asthma, King's College London, London, UK.
M CastellsDivision of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
D DombrowiczINSERM, CHU Lille, European Genomic Institute of Diabetes, Institut Pasteur de Lille, U1011 - récepteurs nucléaires, maladies cardiovasculaires et diabète, Université de Lille, Lille, France.
T R Daniels-WellsDivision of Surgical Oncology, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
J FazekasThe Interuniversity Messerli Research Institute, University of Veterinary Medicine Vienna, Medical University of Vienna, Vienna, Austria.
E FiebigerDivision of Gastroenterology, Hepatology and Nutrition Research, Department of Medicine Research, Children's University Hospital Boston, Boston, MA, USA.
S GataultLIRIC-Unité Mixte de Recherche 995 INSERM, Université de Lille 2, CHRU de Lille, Lille, France.
H J GouldDivision of Asthma, Allergy and Lung Biology, Medical Research Council and Asthma UK Centre in Allergic Mechanisms in Asthma, King's College London, London, UK.
J JandaCenter Pigmod, Institute of Animal Physiology and Genetics, Academy of Sciences of Czech Republic, Libechov, Czech Republic.
D H JosephsDivision of Genetics & Molecular Medicine, Faculty of Life Sciences and Medicine, St. John's Institute of Dermatology, King's College London, London, UK.
P KaragiannisDivision of Genetics & Molecular Medicine, Faculty of Life Sciences and Medicine, St. John's Institute of Dermatology, King's College London, London, UK.
F Levi-SchafferPharmacology and Experimental Therapeutics Unit, Faculty of Medicine, School of Pharmacy, The Institute for Drug Research, The Hebrew University of Jerusalem, Jerusalem, Israel.
A MeshcheryakovaInstitute of Pathophysiology & Allergy Research, Center of Pathophysiology, Infectiology & Immunology, Medical University Vienna, Vienna, Austria.
D MechtcheriakovaInstitute of Pathophysiology & Allergy Research, Center of Pathophysiology, Infectiology & Immunology, Medical University Vienna, Vienna, Austria.
Y MekoriSackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
F MungenastInstitute of Pathophysiology & Allergy Research, Center of Pathophysiology, Infectiology & Immunology, Medical University Vienna, Vienna, Austria.
E A NigroIRCCS San Raffaele Scientific Institute, Milan, Italy.
M L PenichetDivision of Surgical Oncology, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
F RedegeldDivision of Pharmacology, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.
L SaulDivision of Genetics & Molecular Medicine, Faculty of Life Sciences and Medicine, St. John's Institute of Dermatology, King's College London, London, UK.
J SingerInstitute of Pathophysiology & Allergy Research, Center of Pathophysiology, Infectiology & Immunology, Medical University Vienna, Vienna, Austria.
J F SpicerDivision of Cancer Studies, Faculty of Life Sciences & Medicine, King's College London, Guy's Hospital, London, UK.
A G SiccardiIRCCS San Raffaele Scientific Institute, Milan, Italy.
E SpillnerImmunological Engineering, Department of Engineering, Aarhus University, Aarhus, Denmark.
M C TurnerISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.
E UntersmayrInstitute of Pathophysiology & Allergy Research, Center of Pathophysiology, Infectiology & Immunology, Medical University Vienna, Vienna, Austria.
L VangelistaDepartment of Biomedical Sciences, Nazarbayev University School of Medicine, Astana, Kazakhstan.
S N KaragiannisDivision of Genetics & Molecular Medicine, Faculty of Life Sciences and Medicine, St. John's Institute of Dermatology, King's College London, London, UK.
Guy's Hospital · GBMedical University of Vienna · ATInserm · FRUniversity of Veterinary Medicine Vienna · ATUniversity of California, Los Angeles · USVita-Salute San Raffaele University · ITAarhus University · DKBoston Children's Hospital · USBrigham and Women's Hospital · USCzech Academy of Sciences, Institute of Animal Physiology and Genetics · CZHebrew University of Jerusalem · ILKing's College London · GBNazarbayev University · KZTel Aviv University · ILUniversity of Ottawa · CAUtrecht University · NL

Funding

STRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI JONATHAN C KAGAN · 1986 to 2026
$32.4M
A Novel Anti-HER2/neu IgE for Breast Cancer TherapyR01CA181115 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PENICHET, MANUEL L · 2014 to 2018
$2.5M
A Novel IgE Cancer Therapeutic Specific for the Epithelial Membrane Protein-2R21CA179680 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DANIELS-WELLS, TRACY RUTH · 2013 to 2014
$362k
Austrian Science Fund FWF KLI 284Austrian Science Fund FWF P 23228Medical Research Council G1000758Medical Research Council G1100090Medical Research Council MR/L023091/1NCI NIH HHS R01 CA181115NCI NIH HHS R21 CA179680NIDDK NIH HHS P30 DK034854
6 · The paper itself

Abstract

Th2 immunity and allergic immune surveillance play critical roles in host responses to pathogens, parasites and allergens. Numerous studies have reported significant links between Th2 responses and cancer, including insights into the functions of IgE antibodies and associated effector cells in both antitumour immune surveillance and therapy. The interdisciplinary field of AllergoOncology was given Task Force status by the European Academy of Allergy and Clinical Immunology in 2014. Affiliated expert groups focus on the interface between allergic responses and cancer, applied to immune surveillance, immunomodulation and the functions of IgE-mediated immune responses against cancer, to derive novel insights into more effective treatments. Coincident with rapid expansion in clinical application of cancer immunotherapies, here we review the current state-of-the-art and future translational opportunities, as well as challenges in this relatively new field. Recent developments include improved understanding of Th2 antibodies, intratumoral innate allergy effector cells and mediators, IgE-mediated tumour antigen cross-presentation by dendritic cells, as well as immunotherapeutic strategies such as vaccines and recombinant antibodies, and finally, the management of allergy in daily clinical oncology. Shedding light on the crosstalk between allergic response and cancer is paving the way for new avenues of treatment.

Indexed as

AntibodiesHumansHypersensitivityImmunoglobulin EImmunologic SurveillanceImmunotherapyNeoplasmsTh2 CellsAntibodiesImmunoglobulin EAllergoOncologyallergyatopybiologics, desensitizationcancerchemotherapeuticclinical oncologyIgEIgG4inflammationtumor

Identifiers

PMID28032353
PMCPMC5498751
OpenAlexW2563557869

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.