Evidence map›Paper›PMID 28033687›Full record

Trial reportAmerican journal of hematology2017

Thrombospondin-1 gene polymorphism is associated with estimated pulmonary artery pressure in patients with sickle cell anemia.

Seethal A Jacob, Enrico M Novelli, Jeffrey S Isenberg, Melanie E Garrett, Yanxia Chu, Karen Soldano, Kenneth I Ataga, Marilyn J Telen, Allison Ashley-Koch, Mark T Gladwin and 2 more

Open access · bronzeAbstract readClinical TrialLetter
In one paragraph

Trial report in American journal of hematology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Transcriptomic Study on the Lungs of Broilers with Ascites Syndrome.Animals : an open access journal from MDPI · 2023
    Article
  5. Association ofFrontiers in aging neuroscience · 2022
    Article
  6. Article
  7. Article
  8. THBS1 (thrombospondin-1).Atlas of genetics and cytogenetics in oncology and haematology · 2020
    Article
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Seethal A JacobDivision of Hematology/Oncology, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.ORCID 0000-0003-2906-6102
Enrico M NovelliDivision of Hematology-Oncology, University of Pittsburgh, Pittsburgh, Pennsylvania.
Jeffrey S IsenbergHeart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania.
Melanie E GarrettDuke Molecular Physiology Institute, Duke University Medical Center, Durham, North Carolina.
Yanxia ChuPulmonary, Allergy, Critical Care Medicine Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Karen SoldanoDuke Molecular Physiology Institute, Duke University Medical Center, Durham, North Carolina.
Kenneth I AtagaDivision of Hematology/Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Marilyn J TelenDivision of Hematology, Department of Medicine, and Duke Comprehensive Sickle Cell Center, Duke University Medical Center, Durham, North Carolina.
Allison Ashley-KochDuke Molecular Physiology Institute, Duke University Medical Center, Durham, North Carolina.
Mark T GladwinHeart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania.
Yingze ZhangHeart, Lung, Blood, and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania.
Gregory J KatoDivision of Hematology-Oncology, University of Pittsburgh, Pittsburgh, Pennsylvania.ORCID 0000-0003-4465-3217
University of Pittsburgh · USDuke Medical Center · USChildren's Hospital of Pittsburgh · USDuke University · USUniversity of North Carolina at Chapel Hill · US

Funding

Novel role of smooth muscle B5 reductase in Sickle Cell DiseaseR01HL133864 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STRAUB, ADAM CARL · 2016 to 2019
$2.4M
SCN5A gene and prolonged QT in sickle cell diseaseR01MD009162 · NIMHD · UNIVERSITY OF MISSISSIPPI MED CTR · PI MAHER, JOSEPH F, MAJUMDAR, SUVANKAR · 2015 to 2019
$1.8M
Characterizing mechanisms of sickle cell crisis via dynamic optical assayR01HL121386 · NHLBI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SO, PETER T. · 2014 to 2016
$1.7M
Platelet TSP1 Mediates Vascular Disease and pulmonary hypertension in Sickle CellK23HL112848 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NOVELLI, ENRICO M · 2013 to 2017
$729k
NHLBI NIH HHS K23 HL112848NHLBI NIH HHS R01 HL121386NHLBI NIH HHS R01 HL133864NIMHD NIH HHS R01 MD009162
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Anemia, Sickle CellBlood PressureHypertension, PulmonaryPolymorphism, Single NucleotideFemaleHumansMalePulmonary ArteryThrombospondin 1Thrombospondin 1thrombospondin-1, human

Identifiers

PMID28033687
PMCPMC5303556
OpenAlexW2561412179

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.