Evidence map›Paper›PMID 28038939›Full record

ArticleExperimental and molecular pathology2017

Skin fragility in the wild-derived, inbred mouse strain Mus pahari/EiJ.

C Herbert Pratt, Christopher S Potter, Raoul V Kuiper, Son Yong Karst, Soheil S Dadras, Derry C Roopenian, John P Sundberg

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental and molecular pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 87% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. The Sikkim mouse (bioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

C Herbert PrattThe Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609-1500, USA. Electronic address: Herbert.Pratt@jax.org.
Christopher S PotterThe Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609-1500, USA.
Raoul V KuiperDept. of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
Son Yong KarstThe Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609-1500, USA.
Soheil S DadrasDept. of Dermatology, University of Connecticut Health Center, Farmington, CT, USA; Dept. of Genetics/Developmental Biology, University of Connecticut Health Center, Farmington, CT, USA.
Derry C RoopenianThe Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609-1500, USA.
John P SundbergThe Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609-1500, USA.
Jackson Laboratory · USKarolinska Institutet · SEUConn Health · US

Funding

Shared Resource ManagementP30CA034196 · NCI · JACKSON LABORATORY · PI Paul Robson · 1985 to 2026
$61.9M
Discovering Novel Gene Networks for Skin DiseasesR21AR063781 · NIAMS · JACKSON LABORATORY · PI SUNDBERG, JOHN PAUL · 2013 to 2014
$422k
NCI NIH HHS P30 CA034196NIAMS NIH HHS R21 AR063781
6 · The paper itself

Abstract

Mus pahari is a wild-derived, inbred mouse strain. M. pahari colony managers observed fragility of this strain's skin resulting in separation of tail skin from the mouse if handled incorrectly. Tail skin tension testing of M. pahari resulted in significantly lowered force threshold for caudal skin rupture and loss in comparison to closely related inbred mouse species and subspecies and even more than a model for junctional epidermolysis bullosa. Histologically, the tail skin separated at the subdermal level with the dermis firmly attached to the epidermis, excluding the epidermolysis bullosa complex of diseases. The dermal collagen bundles were abnormally thickened and branched. Elastin fiber deposition was focally altered in the dermis adjacent to the hair follicle. Collagens present in the skin could not be differentiated between the species in protein gels following digestion with pepsin. Together these data suggest that M. pahari have altered extracellular matrix development resulting in separation of the skin below the level of the dermis with moderate force similar to the African spiny mouse (Acomys spp.).

Indexed as

TailAnimalsCollagenDermisElasticityElastinMice, Inbred C57BLMice, Inbred StrainsSkinSpecies SpecificityCollagenElastinCollagenElastin fibersInbredMouseSkin fragilityWild-derived

Identifiers

PMID28038939
PMCPMC5331852
OpenAlexW2566622212

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.