Evidence map›Paper›PMID 28039287›Full record

Trial reportBMJ open2016

Vascular biomarkers to predict response to exercise in Alzheimer's disease: the study protocol.

Danni Li, Robin Thomas, Michael Y Tsai, Ling Li, David M Vock, Susan Greimel, Fang Yu

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01954550 (Aerobic Exercise in Alzheimer's Disease), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01954550 nacompletednot on this map

Aerobic Exercise in Alzheimer's Disease: Cognition and Hippocampal Volume Effects

TypeinterventionalSponsorUniversity of MinnesotaRan2014 to 2021Enrolled96ConditionsAlzheimer's Disease, Late OnsetArmsCycling exercise, Range of motion/stretching exercise
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Danni LiDepartment of Laboratory Medicine and Pathology, University of Minnesota, Twin Cities, Minneapolis, Minnesota, USA.
Robin ThomasDepartment of Laboratory Medicine and Pathology, University of Minnesota, Twin Cities, Minneapolis, Minnesota, USA.
Michael Y TsaiDepartment of Laboratory Medicine and Pathology, University of Minnesota, Twin Cities, Minneapolis, Minnesota, USA.
Ling LiDepartment of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Twin Cities, Minneapolis, Minnesota, USA.
David M VockDivision of Biostatistics, School of Public Health, University of Minnesota, Twin Cities, Minneapolis, Minnesota, USA.
Susan GreimelSchool of Nursing, University of Minnesota, Twin Cities, Minneapolis, Minnesota, USA.
Fang YuSchool of Nursing, University of Minnesota, Twin Cities, Minneapolis, Minnesota, USA.
University of Minnesota · USTwin Cities Orthopedics · US

Funding

Aerobic Exercise in Alzheimer's Disease: Cognition and Hippocampal Volume EffectsR01AG043392 · NIA · UNIVERSITY OF MINNESOTA · PI YU, FANG · 2013 to 2018
$3.2M
NIA NIH HHS R01 AG043392
6 · The paper itself

Abstract

introductionExercise interventions are a promising treatment for improving cognition in persons with Alzheimer's disease. This is similar to Alzheimer's disease pharmacotherapies in which only 18-48% of treated patients demonstrate improvement in cognition. Aerobic exercise interventions positively affect brain structure and function through biologically sound pathways. However, an under-studied mechanism of aerobic exercise's effects is n-3 fatty acids in plasma. The objective of this pilot study is to inform a future large-scale study to develop n-3 fatty acids-based prediction of cognitive responses to aerobic exercise treatment in Alzheimer's disease. METHODS AND ANALYSIS: This study will recruit and follow a cohort of 25 subjects enrolled in the FIT-AD Trial, an ongoing randomised controlled trial that investigates the effects of a 6-month moderate-intensity cycling intervention on cognition and hippocampal volume in older adults with mild to moderate Alzheimer's disease over a year. This study will collect blood from subjects at baseline and at 3 and 6 months to assay vascular biomarkers (ie, plasma fatty acids). Global cognition as measured by the Alzheimer's Disease Assessment Scale-Cognition (ADAS-Cog) at baseline, 3, 6, 9 and 12 months will be used as the main outcome. A multiple linear-regression model will be used with 12-month change in cognition as the outcome and baseline measure of n-3 fatty acids or changes in the ratio of n-3 to n-6 fatty-acid levels in plasma at 3 and/or 6 months, randomised treatment group, and their interaction as predictors. ETHICS AND DISSEMINATION: We have obtained Institutional Review Board approval for our study. We obtain consent or assent/surrogate consent from all subjects depending on their consenting capacity assessment. Data of this study are/will be stored in the Research Electronic Data Capture (REDCap). We plan to present and publish our study findings through presentations and manuscripts. TRIAL REGISTRATION NUMBER: NCT01954550.

Indexed as

Exercise TherapyAgedAlzheimer DiseaseApolipoproteins EBicyclingBiomarkersClinical ProtocolsCognitionDisease ProgressionFatty Acids, Omega-3FemaleHippocampusHumansMaleMiddle AgedMinnesotaApolipoproteins EBiomarkersFatty Acids, Omega-3Alzheimer’s diseaseExerciseFatty AcidsPhospholipidsVascular biomarkers

Identifiers

PMID28039287
PMCPMC5223628
OpenAlexW2561721813

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.