Evidence map›Paper›PMID 28053978›Full record

ArticleBioMed research international2016

Proteomic Profiling of Neuroblastoma Cells Adhesion on Hyaluronic Acid-Based Surface for Neural Tissue Engineering.

Ming-Hui Yang, Ko-Chin Chen, Pei-Wen Chiang, Tze-Wen Chung, Wan-Jou Chen, Pei-Yu Chu, Sharon Chia-Ju Chen, Yi-Shan Lu, Cheng-Hui Yuan, Ming-Chen Wang and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. 3D cell culture model: From ground experiment to microgravity study.Frontiers in bioengineering and biotechnology · 2023
    Review
  2. Hydrogels: Properties and Applications in Biomedicine.Molecules (Basel, Switzerland) · 2022
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 2 countries.

Ming-Hui YangCenter for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung 807, Taiwan.ORCID 0000-0001-5856-0498
Ko-Chin ChenDepartment of Pathology, Changhua Christian Hospital, Changhua 500, Taiwan.
Pei-Wen ChiangDepartment of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Tze-Wen ChungDepartment of Biomedical Engineering, National Yang-Ming University, Taipei 112, Taiwan.ORCID 0000-0002-7469-9913
Wan-Jou ChenDepartment of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan.ORCID 0000-0001-5817-8627
Pei-Yu ChuDepartment of Laboratory Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan; Department of Medical Laboratory Science and Biotechnology, College of Health Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Sharon Chia-Ju ChenDepartment of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan.ORCID 0000-0002-9238-7112
Yi-Shan LuOffice of Safety, Health and Environment, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Cheng-Hui YuanMass Spectrometry Laboratory, Chemical, Molecular and Materials Analysis Center, Department of Chemistry, National University of Singapore, Singapore 119077.
Ming-Chen WangDepartment of Biomedical Engineering, Chung Yuan Christian University, Chungli 300, Taiwan.
Chia-Yang LinDepartment of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan; Department of Nuclear Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.
Ying-Fong HuangDepartment of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan; Department of Nuclear Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.
Shiang-Bin JongDepartment of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan; Department of Nuclear Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.
Po-Chiao LinDepartment of Chemistry, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
Yu-Chang TyanCenter for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung 807, Taiwan; Department of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung 807, Taiwan; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan; Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung 804, Taiwan.ORCID 0000-0002-1917-5893
Kaohsiung Medical University · TWNational Sun Yat-sen University · TWChanghua Christian Hospital · TWChung Yuan Christian University · TWNational University of Singapore · SGNational Yang Ming Chiao Tung University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The microenvironment of neuron cells plays a crucial role in regulating neural development and regeneration. Hyaluronic acid (HA) biomaterial has been applied in a wide range of medical and biological fields and plays important roles in neural regeneration. PC12 cells have been reported to be capable of endogenous NGF synthesis and secretion. The purpose of this research was to assess the effect of HA biomaterial combining with PC12 cells conditioned media (PC12 CM) in neural regeneration. Using SH-SY5Y cells as an experimental model, we found that supporting with PC12 CM enhanced HA function in SH-SY5Y cell proliferation and adhesion. Through RP-nano-UPLC-ESI-MS/MS analyses, we identified increased expression of HSP60 and RanBP2 in SH-SY5Y cells grown on HA-modified surface with cotreatment of PC12 CM. Moreover, we also identified factors that were secreted from PC12 cells and may promote SH-SY5Y cell proliferation and adhesion. Here, we proposed a biomaterial surface enriched with neurotrophic factors for nerve regeneration application.

Indexed as

Tissue EngineeringAnimalsCell AdhesionCell ProliferationCellular MicroenvironmentChaperonin 60Gene Expression Regulation, DevelopmentalHumansHyaluronic AcidMitochondrial ProteinsMolecular ChaperonesNerve RegenerationNeuroblastomaNeuronsNuclear Pore Complex ProteinsPC12 CellsChaperonin 60Hspd1 protein, ratHyaluronic AcidMitochondrial ProteinsMolecular ChaperonesNuclear Pore Complex Proteinsran-binding protein 2

Identifiers

PMID28053978
PMCPMC5174748
OpenAlexW2560648729

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.