Evidence map›Paper›PMID 28062526›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2017

Regulation of Chemokine Signal Integration by Activator of G-Protein Signaling 4 (AGS4).

William G Robichaux, Melissa Branham-O'Connor, Il-Young Hwang, Ali Vural, Johne H Kehrl, Joe B Blumer

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

William G RobichauxDepartment of Cell and Molecular Pharmacology and Experimental Therapeutics, Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina (W.G.R., M.B.-O., J.B.B.); and B-Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland (I.-Y.H., A.V., J.H.K.).
Melissa Branham-O'ConnorDepartment of Cell and Molecular Pharmacology and Experimental Therapeutics, Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina (W.G.R., M.B.-O., J.B.B.); and B-Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland (I.-Y.H., A.V., J.H.K.).
Il-Young HwangDepartment of Cell and Molecular Pharmacology and Experimental Therapeutics, Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina (W.G.R., M.B.-O., J.B.B.); and B-Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland (I.-Y.H., A.V., J.H.K.).
Ali VuralDepartment of Cell and Molecular Pharmacology and Experimental Therapeutics, Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina (W.G.R., M.B.-O., J.B.B.); and B-Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland (I.-Y.H., A.V., J.H.K.).
Johne H KehrlDepartment of Cell and Molecular Pharmacology and Experimental Therapeutics, Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina (W.G.R., M.B.-O., J.B.B.); and B-Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland (I.-Y.H., A.V., J.H.K.).
Joe B BlumerDepartment of Cell and Molecular Pharmacology and Experimental Therapeutics, Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina (W.G.R., M.B.-O., J.B.B.); and B-Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland (I.-Y.H., A.V., J.H.K.) blumerjb@musc.edu.
Medical University of South Carolina · USNational Institutes of Health · US

Funding

South Carolina IDeA Networks of Biomedical Research (SC INBRE V)P20GM103499 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI EDIE C GOLDSMITH · 2012 to 2026
$61.0M
Translational Science Laboratory Shared ResourceP30CA138313 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI John J Lemasters · 2009 to 2026
$42.7M
Analysis of the Functional Roles of a Novel G-alpha Nucleotide CycleZIAAI000961 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI KEHRL, JOHN H · 2009 to 2018
$4.4M
STRUCTURAL ANALYSIS OF THE ALPHA-2 ADRENERGIC RECEPTORR01NS024821 · NINDS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI LANIER, STEPHEN M. · 1994 to 2007
$2.4M
MUSC FACIL EXPANSION &RENOV: SLE C06RR015455 · NCRR · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI RAYMOND, JOHN R · 2002 to 2002
$2.0M
ACCESSORY PROTEINS AND G-PROTEIN SIGNALING MECHANISMSR01DA025896 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI LANIER, STEPHEN M. · 2008 to 2012
$1.6M
AGS4 in G-protein Signal ProcessingR01GM086510 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BLUMER, JOE B · 2009 to 2013
$1.5M
TRAINING IN CANCER THERAPEUTICST32CA119945 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI TEW, KENNETH D. · 2006 to 2010
$1.3M
NCI NIH HHS P30 CA138313NCI NIH HHS T32 CA119945NCRR NIH HHS C06 RR015455NIDA NIH HHS R01 DA025896NIGMS NIH HHS P20 GM103499NIGMS NIH HHS R01 GM086510NINDS NIH HHS R01 NS024821
6 · The paper itself

Abstract

Activator of G-protein signaling 4 (AGS4)/G-protein signaling modulator 3 (Gpsm3) contains three G-protein regulatory (GPR) motifs, each of which can bind G

Indexed as

AnimalsChemokinesChemotactic FactorsChemotaxis, LeukocyteDendritic CellsExtracellular Signal-Regulated MAP KinasesGuanine Nucleotide Dissociation InhibitorsHeterotrimeric GTP-Binding ProteinsMiceNeutrophilsRGS ProteinsSignal TransductionT-LymphocytesChemokinesChemotactic FactorsExtracellular Signal-Regulated MAP KinasesG18 protein, mouseGuanine Nucleotide Dissociation InhibitorsHeterotrimeric GTP-Binding ProteinsRGS4 proteinRGS Proteins

Identifiers

PMID28062526
PMCPMC5325072
OpenAlexW2570881722

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.