Evidence map›Paper›PMID 28063503›Full record

Trial reportNutrition (Burbank, Los Angeles County, Calif.)2017

Does oral glutamine improve insulin sensitivity in adolescents with type 1 diabetes?

Lournaris Torres-Santiago, Nelly Mauras, Jobayer Hossain, Arthur L Weltman, Dominique Darmaun

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrition (Burbank, Los Angeles County, Calif.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01467063 (Dietary Amino Acids and Insulin Sensitivity in Children With Type 1 Diabetes), which is not on this map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01467063 nacompletednot on this map

Dietary Amino Acids and Insulin Sensitivity in Children With Type 1 Diabetes

TypeinterventionalSponsorNemours Children's ClinicRan2011 to 2013Enrolled13ConditionsType I Diabetes MellitusArmsGlutamine, Placebo
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Lournaris Torres-SantiagoDepartment of Pediatric Endocrinology and Metabolism, Nemours Children's Health System, Jacksonville, Florida, USA.
Nelly MaurasDepartment of Pediatric Endocrinology and Metabolism, Nemours Children's Health System, Jacksonville, Florida, USA.
Jobayer HossainBiostatistics Core, Nemours/A. I. duPont Hospital for Children, Wilmington, Delaware, USA.
Arthur L WeltmanDepartment of Kinesiology, Department of Medicine, University of Virginia, Charlottesville, Virginia, USA.
Dominique DarmaunDepartment of Pediatric Endocrinology and Metabolism, Nemours Children's Health System, Jacksonville, Florida, USA; INRA and University of Nantes, Nantes, France. Electronic address: Ddarmaun@nemours.org.
Nemours Children's Health System · USCommunity Health Systems - Dupont Hospital · USNantes Université · FRUniversity of Virginia · US

Funding

Subproject Title: Clinical Research Education, Mentoring and Career Development CoreU54GM104941 · NIGMS · UNIVERSITY OF DELAWARE · PI LEE M PACHTER · 2013 to 2026
$60.5M
NIGMS NIH HHS U54 GM104941
6 · The paper itself

Abstract

objectiveThe decline in insulin sensitivity (S

methodsThirteen adolescents with T1D (HbA1C 8.2 ± 0.1%) were admitted to perform afternoon exercise (four 15-min treadmill/5-min rest cycles of exercise) on two occasions within a 4-wk period. They were randomized to receive a drink containing either glutamine (0.25 g/kg) or placebo before exercise, at bedtime, and early morning in a double-blind, crossover design. Blood glucose was monitored overnight, and a hyperinsulinemic-euglycemic clamp was performed the following morning.

resultsBlood glucose concentration dropped comparably during exercise on both days. However, the total number of nocturnal hypoglycemic events (17 versus 7, P = 0.045) and the cumulative probability of overnight hypoglycemia (50% versus 33%, P = 0.02) were higher on the glutamine day than on the placebo day. During clamp, glucose infusion rate was not affected by glutamine supplementation (7.7 ± 1 mg • kg

conclusionsOral glutamine supplementation decreases blood glucose in adolescents with T1D after exercise. Insulin sensitivity, however, was unaltered during the euglycemic clamp. Although the mechanisms involved remain to be elucidated, studies to explore the potential use of glutamine to improve blood glucose control are needed.

Indexed as

ExerciseInsulin ResistanceAdolescentBlood GlucoseBody Mass IndexCross-Over StudiesDiabetes Mellitus, Type 1Dietary SupplementsDouble-Blind MethodFatty Acids, NonesterifiedFemaleGlucagon-Like Peptide 1Glucose Clamp TechniqueGlutamineHumansHypoglycemiaBlood GlucoseFatty Acids, NonesterifiedGlucagon-Like Peptide 1GlutamineHypoglycemic AgentsInsulinAmino acidsExerciseGLP-1Hyperinsulinemic-euglycemic clamp clampHypoglycemiaStable isotopes

Identifiers

PMID28063503
PMCPMC5656227
OpenAlexW2523566345

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.