Evidence map›Paper›PMID 28067785›Full record

ArticleBrain sciences2017

Relationships between GAT1 and PTSD, Depression, and Substance Use Disorder.

Kaitlin E Bountress, Wei Wei, Christina Sheerin, Dongjun Chung, Ananda B Amstadter, Howard Mandel, Zhewu Wang

Open access · goldAbstract read
In one paragraph

Article in Brain sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 15 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Kaitlin E BountressDepartment of Psychiatry, Medical University of South Carolina, Charleston, SC 29425, USA. bountres@musc.edu.
Wei WeiDepartment of Public Health Sciences, Medical University of South Carolina, Charleston, SC 29425-8350, USA. weiwe@musc.edu.
Christina SheerinVirginia Institute for Psychiatry and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23219-1534, USA. Christina.sheerin@gmail.com.
Dongjun ChungDepartment of Public Health Sciences, Medical University of South Carolina, Charleston, SC 29425-8350, USA. chungd@musc.edu.
Ananda B AmstadterVirginia Institute for Psychiatry and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23219-1534, USA. Ananda.Amstadter@vcuhealth.org.
Howard MandelRalph H. Johnson VA Medical Center, Charleston, SC 29401, USA. mandel@musc.edu.
Zhewu WangDepartment of Psychiatry, Medical University of South Carolina, Charleston, SC 29425, USA. wanzh@musc.edu.
Medical University of South Carolina · USVirginia Commonwealth University · USRalph H. Johnson VA Medical Center · US

Funding

VCU NIMHD Comprehensive Center of Excellence (Project 1; PI: Strauss)P60MD002256 · NIMHD · VIRGINIA COMMONWEALTH UNIVERSITY · PI YORK, TIMOTHY P · 2007 to 2016
$13.1M
Traumatic Stress Across the Lifespan: A Biopsychosocial Training ProgramT32MH018869 · NIMH · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI CARLA KMETT DANIELSON, DEAN Gaines KILPATRICK · 1988 to 2026
$7.2M
Research Training: Psychiatric &Statistical GeneticsT32MH020030 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI HERMINE H MAES, MICHAEL CHURTON NEALE · 1999 to 2026
$6.7M
Genetic Contributions of Negative Valence Systems to Internalizing PathwaysR01MH101518 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI ROBERSON-NAY, ROXANN · 2013 to 2016
$2.3M
Statistical Models for Genetic Studies, Using Network and Integrative AnalysisR01GM122078 · NIGMS · OHIO STATE UNIVERSITY · PI CHUNG, DONGJUN · 2016 to 2020
$1.9M
Stress-induced Drinking in OEF/OIF Veterans: The Role of Combat History and PTSDR01AA020179 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI AMSTADTER, ANANDA B · 2010 to 2014
$1.6M
Stress-induced drinking in Returning Soldiers: Genetic and Epigenetic MechanismsK02AA023239 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI AMSTADTER, ANANDA B · 2014 to 2018
$643k
Sex Gender Differences in Post Traumatic Stress DisorderR21MH103686 · NIMH · RAND CORPORATION · PI MARSHALL, GRANT · 2014 to 2015
$455k
Algorithms for Literature-Guided Multi-Platform Identification of Cancer SubtypesR21CA209848 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI CHUNG, DONGJUN, KELEMEN, LINDA E · 2016 to 2017
$358k
CSRD VA I01 CX000487NCI NIH HHS R21 CA209848NIAAA NIH HHS K02 AA023239NIAAA NIH HHS R01 AA020179NIGMS NIH HHS R01 GM122078NIMHD NIH HHS P60 MD002256NIMH NIH HHS R01 MH101518NIMH NIH HHS R21 MH103686NIMH NIH HHS T32 MH018869NIMH NIH HHS T32 MH020030
6 · The paper itself

Abstract

Post-traumatic stress disorder (PTSD), Major Depressive Disorder (MDD), and Substance Use Disorder (SUD) have large public health impacts. Therefore, researchers have attempted to identify those at greatest risk for these phenotypes. PTSD, MDD, and SUD are in part genetically influenced. Additionally, genes in the glutamate and gamma-aminobutyric acid (GABA) system are implicated in the encoding of emotional and fear memories, and thus may impact these phenotypes. The current study examined the associations of single nucleotide polymorphisms in

Indexed as

GAT1major depressive disorderpost-traumatic stress disordersubstance use disorderveterans

Identifiers

PMID28067785
PMCPMC5297295
OpenAlexW2568632772

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.