Trial reportJournal of the American Geriatrics Society2017
Effect of a Long-Term Intensive Lifestyle Intervention on Cognitive Function: Action for Health in Diabetes Study.
Trial report in Journal of the American Geriatrics Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 41 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Look AHEAD: Action for Health in Diabetes
Evaluation and Follow up of Emotional Regulation, Cognition, Impulsivity and Reward System in Obesity, and Determination of Its Biopsychosocial Risk Factors: A Prospective Study of Obese Patients Before and After Bariatric Surgery
Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Effect of Exercise on the Cognitive Function of Older Patients With Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.Frontiers in human neuroscience · 2022Pooled it
- Long-term effects of a multidomain intervention on cognitive function and metabolic control in older adults with type 2 diabetes and mild cognitive impairment: A 42-month follow-up of the J-MIND-Diabetes study.Diabetes, obesity & metabolism · 2026Trial
- Late-life disability following the action for health in diabetes (Look AHEAD) trial.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Trial
- Alzheimer Disease Blood Biomarkers and Cognition Among Individuals With Diabetes and Overweight or Obesity.JAMA network open · 2025Trial
- Multidomain Intervention Trial for Preventing Cognitive Decline among Older Adults with Type 2 Diabetes: J-MIND-Diabetes.The journal of prevention of Alzheimer's disease · 2024Trial
- A randomized controlled trial examining the effects of behavioral weight loss treatment on hippocampal volume and neurocognition.Physiology & behavior · 2023Trial
- Association of Type 2 Diabetes Subgroups With Cognitive Status Without Modification From Lifestyle Intervention.The Journal of clinical endocrinology and metabolism · 2023Trial
- Associations between cognitive function and endogenous levels of estradiol and testosterone in adults with type 2 diabetes.Journal of diabetes and its complications · 2022Trial
- Association of cognition with leptin and vascular endothelial growth factor in individuals with type 2 diabetes mellitus.Obesity (Silver Spring, Md.) · 2022Trial
- Eight-Year Changes in Multimorbidity and Frailty in Adults With Type 2 Diabetes Mellitus: Associations With Cognitive and Physical Function and Mortality.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Trial
- Legacy of a 10-Year Multidomain Lifestyle Intervention on the Cognitive Trajectories of Individuals with Overweight/Obesity and Type 2 Diabetes Mellitus.Dementia and geriatric cognitive disorders · 2021Trial
- Long-term Change in Physiological Markers and Cognitive Performance in Type 2 Diabetes: The Look AHEAD Study.The Journal of clinical endocrinology and metabolism · 2020Trial
- Impact of a Multidomain Intensive Lifestyle Intervention on Complaints About Memory, Problem-Solving, and Decision-Making Abilities: The Action for Health in Diabetes Randomized Controlled Clinical Trial.The journals of gerontology. Series A, Biological sciences and medical sciences · 2018Trial
- Sex-related differences in the prevalence of cognitive impairment among overweight and obese adults with type 2 diabetes.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2018Trial
- Long-term Impact of Weight Loss Intervention on Changes in Cognitive Function: Exploratory Analyses from the Action for Health in Diabetes Randomized Controlled Clinical Trial.The journals of gerontology. Series A, Biological sciences and medical sciences · 2018Trial
- Reversal of early-life high fat diet prevents spatial discrimination deficits corresponding with altered brain inflammatory and metabolic profiles in male C57BL/6J mice.Nutritional neuroscience · 2026Article
- Dietary and exercise interventions improve cognition and alter hippocampal transcriptomics in a mouse model of the metabolic syndrome.Experimental neurology · 2025Article
- Long-term outcomes of a Mediterranean diet with or without calorie restriction on cognition and cardiometabolic health: The building research in diet and cognition trial.Preventive medicine reports · 2025Article
- Nutrition and Aging Biology: Summary of a Research Centers Collaborative Network Workshop and Research Needs.Current developments in nutrition · 2025Article
- Twenty-year trajectories of cardio-metabolic factors among people with type 2 diabetes by dementia status in England: a retrospective cohort study.European journal of epidemiology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 11 institutions in 1 country.
Funding
Abstract
objectivesTo assess whether randomization to 10 years of lifestyle intervention to induce and maintain weight loss improves cognitive function.
designRandomized controlled clinical trial.
settingData obtained as part of the Action for Health in Diabetes (Look AHEAD) trial (NCT00017953) and Look AHEAD Continuation study (U01 DK057136-15).
participantsOverweight and obese individuals with type 2 diabetes mellitus aged 45 to 76 (N = 3,751).
interventionIntensive lifestyle intervention (ILI) for weight loss through reduced caloric intake and increased physical activity compared with a control condition of diabetes support and education (DSE). MEASUREMENTS: Certified examiners who were masked to intervention assignment administered a standard battery of cognitive function tests (Modified Mini-Mental State Examination, Rey Auditory Verbal Learning Test, Digit Symbol Coding, Trail-Making Test, Modified Stroop Color-Word Test) to participants 10 to 13 years after enrollment.
resultsAssignment to lifestyle intervention was not associated with significantly different overall (P = .10) or domain-specific (all P > .10) cognitive function than assignment to diabetes support and education. Results were fairly consistent across prespecified groups, but there was some evidence of trends for differential intervention effects showing modest harm in ILI in participants with greater body mass index and in individuals with a history of cardiovascular disease. Cognitive function was not associated with changes in weight or fitness (all P > .05).
conclusionA long-term behavioral weight loss intervention for overweight and obese adults with diabetes mellitus was not associated with cognitive benefit. Trial Registration clinicaltrials.gov Identifier: NCT00017953.
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Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.