ArticleScientific reports2017
Biodegradable Magnesium Screws Accelerate Fibrous Tissue Mineralization at the Tendon-Bone Insertion in Anterior Cruciate Ligament Reconstruction Model of Rabbit.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 53 citations in OpenAlex.
- Biodegradable Magnesium-Based Implants in Sports Orthopedic Surgery: Advances in Alloy Design, Surface Engineering, and Translational Evidence.Bioengineering (Basel, Switzerland) · 2026Review
- [Research progress on the role and mechanism of magnesium element and magnesium materials in tendon-bone interface healing].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026Review
- A long-term quasi-equivalentBioactive materials · 2025Article
- Injectable magnesium-bisphosphonate MOF-based bone adhesive prevents excessive fibrosis for osteoporotic fracture repair.Nature communications · 2025Article
- Application and optimization of bioengineering strategies in facilitating tendon-bone healing.Biomedical engineering online · 2025Review
- Immunoregulative coating for scarless healing in anterior cruciate ligament reconstruction.Bioactive materials · 2025Article
- An overview of magnesium-based implants in orthopaedics and a prospect of its application in spine fusion.Bioactive materials · 2024Review
- [Research progress of magnesium and magnesium alloy implants in sports medicine].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2024Review
- Comparison of Time-Zero Primary Stability Between a Biodegradable Magnesium Bone Staple and Metal Bone Staples for Knee Ligament Fixation: A Biomechanical Study in a Porcine Model.Orthopaedic journal of sports medicine · 2024Article
- Absorbable implants in sport medicine and arthroscopic surgery: A narrative review of recent development.Bioactive materials · 2024Review
- Interference screws manufactured from magnesium display similar primary stability for soft tissue anterior cruciate ligament graft fixation compared to a biocomposite material - a biomechanical study.Journal of experimental orthopaedics · 2023Article
- Degradation behavior of ZE21C magnesium alloy suture anchors and their effect on ligament-bone junction repair.Bioactive materials · 2023Article
- Linguistic Analysis Identifies Emergent Biomaterial Fabrication Trends for Orthopaedic Applications.Advanced healthcare materials · 2023Review
- Plain metallic biomaterials: opportunities and challenges.Regenerative biomaterials · 2023Review
- Strategies for promoting tendon-bone healing: Current status and prospects.Frontiers in bioengineering and biotechnology · 2023Review
- Applications of Biodegradable Magnesium-Based Materials in Reconstructive Oral and Maxillofacial Surgery: A Review.Molecules (Basel, Switzerland) · 2022Review
- Exosomes derived from magnetically actuated bone mesenchymal stem cells promote tendon-bone healing through the miR-21-5p/SMAD7 pathway.Materials today. Bio · 2022Article
- Anterior Cruciate Ligament Reconstruction: Is Biological Augmentation Beneficial?International journal of molecular sciences · 2021Review
- Research status of biodegradable metals designed for oral and maxillofacial applications: A review.Bioactive materials · 2021Review
- Biodegradable metals for bone defect repair: A systematic review and meta-analysis based on animal studies.Bioactive materials · 2021Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The incorporation of tendon graft into bone tunnel is one of the most challenging clinical issues in anterior cruciate ligament (ACL) reconstruction. As a biodegradable metal, Mg has appropriate mechanical strength and osteoinductive effects, thus may be a promising alternative to commercialized products used for graft fixation. Therefore, it was hypothesized that Mg based interference screws would promote tendon graft-bone junction healing when compared to Ti screws. Herein, we compared the effects of Mg and Ti screws on tendon graft healing in rabbits with ACL reconstruction via histological, HR-pQCT and mechanical analysis. The histological results indicated that Mg screws significantly improved the graft healing quality via promoting mineralization at the tendon graft enthesis. Besides, Mg screws significantly promoted bone formation in the peri-screw region at the early healing stage. Importantly, Mg screws exhibited excellent corrosion resistance and the degradation of Mg screws did not induce bone tunnel widening. In tensile testing, there were no significant differences in the load to failure, stress, stiffness and absorption energy between Mg and Ti groups due to the failure mode at the midsubstance. Our findings demonstrate that Mg screws can promote tendon graft healing after ACL reconstruction, implying a potential alternative to Ti screws for clinical applications.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.