Evidence map›Paper›PMID 28086162›Full record

ReviewCurrent opinion in cell biology2017

Getting to and through the inner nuclear membrane during herpesvirus nuclear egress.

Ming F Lye, Adrian R Wilkie, David J Filman, James M Hogle, Donald M Coen

Abstract readReview
In one paragraph

Review in Current opinion in cell biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
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  7. Review
  8. Article
  9. Article
  10. Characterization ofViruses · 2021
    Article
  11. Review
  12. Article
  13. Article
  14. Journal of cell science · 2020
    Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ming F LyeDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 250 Longwood Ave., Boston, MA 02052, United States.
Adrian R WilkieDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 250 Longwood Ave., Boston, MA 02052, United States.
David J FilmanDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 250 Longwood Ave., Boston, MA 02052, United States.
James M HogleDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 250 Longwood Ave., Boston, MA 02052, United States.
Donald M CoenDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 250 Longwood Ave., Boston, MA 02052, United States. Electronic address: don_coen@hms.harvard.edu.
Harvard University · US

Funding

Human Cytomegalovirus Nuclear Egress: Molecular Mechanisms and Drug TargetingR01AI026077 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI COEN, DONALD M · 1999 to 2019
$10.9M
The processes mediating capsid transport during HCMV nuclear egressF31AI120651 · NIAID · HARVARD MEDICAL SCHOOL · PI WILKIE, ADRIAN RAULET · 2015 to 2016
$62k
NIAID NIH HHS F31 AI120651NIAID NIH HHS R01 AI026077
6 · The paper itself

Abstract

Herpesviruses, like most DNA viruses, replicate and package their genomes into capsids in the host cell nucleus. Capsids then transit to the cytoplasm in a fascinating process called nuclear egress, which includes several unusual steps: Movement of capsids from the nuclear interior to the periphery, disruption of the nuclear lamina, capsid budding through the inner nuclear membrane, and fusion of enveloped particles with the outer nuclear membrane. Here, we review recent advances and emerging questions relating to herpesvirus nuclear egress, emphasizing controversies regarding mechanisms for capsid trafficking to the nuclear periphery, and implications of recent structures of the two-subunit, viral nuclear egress complex for the process, particularly at the step of budding through the inner nuclear membrane.

Indexed as

Biological TransportAnimalsCapsidCell NucleusCytoplasmHerpesviridaeHumansModels, MolecularNuclear EnvelopeNuclear Lamina

Identifiers

PMID28086162
PMCPMC5503802
OpenAlexW2567926297

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.