← GLP-1 receptor agonists × blood pressure

TrialDiabetes research and clinical practice2017

The effects of GLP-1 based therapies on postprandial haemodynamics: Two randomised, placebo-controlled trials in overweight type 2 diabetes patients.

Mark M Smits et al.PubMed ↗Publisher ↗

  • Acute exenatide-infusionlooks bad hereHigher postprandial diastolic BP, higher vascular resistance.Randomised, small.

What the trial testedrandomised · 57 people · 2017

Randomised vs placebo

Probably raised postprandial diastolic BP

+6.70+3.60 to +9.90

acute exenatide-infusion vs placebo

As reported

difference 6.7, 95% CI 3.60–9.90

Randomised vs placebo

Probably raised vascular resistance

+684+439 to +929

acute exenatide-infusion vs placebo

As reported

difference 683.6, 95% CI 439–929

Who was studied, and how

57people with hypertension, in this paper

The trial randomly assignedassigned by chance

acute exenatide-infusion
placebo

Probably raised postprandial diastolic BP+6.70

Probably raised vascular resistance+684

randomised

the abstract, start to end

… increased postprandial diastolic BP (6.7 [95%-confidence interval 3.6-9.9]mmHg, p<0.001) and vascular resistance (683.6 [438.5-928.8]dyn*s/cm …

← favours treatmentfavours comparator →
could be chance
Postprandial diastolic BPacute exenatide-infusion vs placebo
6.73.60–9.90
Vascular resistanceacute exenatide-infusion vs placebo
683.6439–929
GLP-1 receptor agonistsBlood pressure

GLP-1 receptor agonists × blood pressurehelps?mixed

unlikelylikely
0.500.92 without it
← favours treatmentfavours comparator →
this papermore certainless certain
1 / 6

8 papers cite it

2017
2018
2019
2020
2021
2022
2023
2024
this paperpooled ittrialcites it
Full record →Abstract, authors, funding and every citing paper · PMID 28086201