ArticleNeuropsychiatric disease and treatment2017
Long-term bicycle riding ameliorates the depression of the patients undergoing hemodialysis by affecting the levels of interleukin-6 and interleukin-18.
Article in Neuropsychiatric disease and treatment, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 5 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Exercise and depression symptoms in chronic kidney disease patients: an updated systematic review and meta-analysis.Renal failure · 2024Pooled it
- Exercise training for adults undergoing maintenance dialysis.The Cochrane database of systematic reviews · 2022Pooled it
- Exercise interventions improve depression and anxiety in chronic kidney disease patients: a systematic review and meta-analysis.International urology and nephrology · 2021Pooled it
- Psychosocial interventions for preventing and treating depression in dialysis patients.The Cochrane database of systematic reviews · 2019Pooled it
- Aerobic exercise in adults with chronic kidney disease (CKD): a meta-analysis.International urology and nephrology · 2019Pooled it
- Depression and the Effect of Sertraline on Inflammatory Biomarkers in Patients with Nondialysis CKD.Kidney360 · 2020Trial
- Effects of Exercise on Inflammatory Markers in Individuals with Chronic Kidney Disease: A Systematic Review and Meta-Analysis.Metabolites · 2023Review
- Study on the Mechanism for SIRT1 during the Process of Exercise Improving Depression.Brain sciences · 2023Review
- Role of Interleukin-6 in Depressive Disorder.International journal of molecular sciences · 2020Review
- A Systematic Review and Meta-Analysis of Depression and Protein-Energy Wasting in Kidney Disease.Kidney international reports · 2020Article
- Serum concentrations of interleukin 18 and 25-hydroxyvitamin D3 correlate with depression severity in men with psoriasis.PloS one · 2018Article
- High intensity resistance training causes muscle damage and increases biomarkers of acute kidney injury in healthy individuals.PloS one · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeHemodialysis patients with depression have a higher risk of death and hospitalization. Although there is pharmacological management for the depression of hemodialysis patients, the adverse effect of the drug limits the use. The nonpharmacological way, bicycle riding, may be an effective way for the therapy of the depression in hemodialysis patients. However, the underlying mechanism of this relationship is still not fully explained, while interleukin-6 (IL-6) and interleukin-18 (IL-18) are associated with depression and exercise. Thus, the effects of bicycle riding on the levels of the interleukin were explored. PARTICIPANTS AND
methodsOne hundred and eighty-nine patients with chronic hemodialysis were selected and randomly assigned to three groups of medicine (MG, received 20-mg escitalopram daily), medicine and aerobic exercise (MAG, received 20-mg escitalopram daily and bicycle riding six times weekly), and only aerobic exercise (AG, received 20-mg placebo daily and bicycle riding six times weekly). The whole experiment lasted for 18 weeks. The quality of life (36-Item Short Form Health Survey) and depression severity according to criteria in the
resultsThe quality of life was improved and depression severity was reduced significantly in the MAG and AG groups when compared with the MG group (
conclusionAerobic exercise improves the quality of life and ameliorates the depression severity of the patients undergoing hemodialysis by affecting the levels of IL-6 and IL-18. Bicycle riding is a potential way for the depression therapy of the patients with chronic hemodialysis.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.