ArticleBMC genomics2017
Genome-wide standing variation facilitates long-term response to bidirectional selection for antibody response in chickens.
Article in BMC genomics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Whole-genome resequencing identifies adaptive variation associated with complex terrain in southwestern Chinese ducks.Poultry science · 2026Article
- Serum biochemical profiles are distinct between White Leghorn chicken lines selected for divergent antibody response to sheep red blood cells.BMC veterinary research · 2026Article
- Deciphering host-virus interaction networks in ALV infection: an integrative multi-omics perspective.Frontiers in immunology · 2026Review
- Genome-wide association study for stayability at different calvings in Nellore beef cattle.BMC genomics · 2024Article
- Tissue cytokines in chickens from lines selected for high or low humoral antibody responses, given supplementalFrontiers in physiology · 2023Article
- Differences in the microbiome of the small intestine of Leghorn lines divergently selected for antibody titer to sheep erythrocytes suggest roles for commensals in host humoral response.Frontiers in physiology · 2023Article
- Pathogenesis and shedding of Usutu virus in juvenile chickens.Emerging microbes & infections · 2021Article
- Article
- Selection for environmental variance of litter size in rabbits involves genes in pathways controlling animal resilience.Genetics, selection, evolution : GSE · 2021Article
- Genome-Wide Association Study of Growth Performance and Immune Response to Newcastle Disease Virus of Indigenous Chicken in Rwanda.Frontiers in genetics · 2021Article
- A quantitative trait locus on chromosome 2 was identified that accounts for a substantial proportion of phenotypic variance of the yellow plumage color in chicken.Poultry science · 2020Article
- CD8Journal of medical virology · 2019Article
- Bidirectional Selection for Body Weight on Standing Genetic Variation in a Chicken Model.G3 (Bethesda, Md.) · 2019Article
- Genotype frequency contributions of Mx1 gene in eight chicken breeds under different selection pressures.3 Biotech · 2018Article
- Genome-wide characterization of genetic variants and putative regions under selection in meat and egg-type chicken lines.BMC genomics · 2018Article
- Gut Microbiota Co-microevolution with Selection for Host Humoral Immunity.Frontiers in microbiology · 2017Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLong-term selection experiments provide a powerful approach to gain empirical insights into adaptation, allowing researchers to uncover the targets of selection and infer their contributions to the mode and tempo of adaptation. Here we implement a pooled genome re-sequencing approach to investigate the consequences of 39 generations of bidirectional selection in White Leghorn chickens on a humoral immune trait: antibody response to sheep red blood cells.
resultsWe observed wide genome involvement in response to this selection regime. Many genomic regions were highly differentiated resulting from this experimental selection regime, an involvement of up to 20% of the chicken genome (208.8 Mb). While genetic drift has certainly contributed to this, we implement gene ontology, association analysis and population simulations to increase our confidence in candidate selective sweeps. Three strong candidate genes, MHC, SEMA5A and TGFBR2, are also presented.
conclusionsThe extensive genomic changes highlight the polygenic genetic architecture of antibody response in these chicken populations, which are derived from a common founder population, demonstrating the extent of standing immunogenetic variation available at the onset of selection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.