Evidence map›Paper›PMID 28100502›Full record

ArticleAmerican journal of physiology. Renal physiology2017

RACK1 regulates angiotensin II-induced contractions of SHR preglomerular vascular smooth muscle cells.

Xiao Zhu, Edwin K Jackson

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Characterization of the NPurinergic signalling · 2020
    Article
  10. Article
  11. DPP4 Inhibition, NPYThe Journal of pharmacology and experimental therapeutics · 2020
    Article
  12. Cardiovascular therapeutics · 2020
    Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Xiao ZhuDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Edwin K JacksonDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania edj@pitt.edu.
University of Pittsburgh · US

Funding

Single Nephron and MetabolomicsP30DK079307 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R · 2008 to 2022
$13.4M
Role of Renal Dipeptidyl Peptidase IVR01HL069846 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JACKSON, EDWIN KERRY · 2003 to 2020
$6.6M
The Guanosine-Adenosine MechanismR01HL109002 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JACKSON, EDWIN KERRY · 2012 to 2023
$5.1M
The Renal 2',3'-cAMP-Adenosine PathwayR01DK068575 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JACKSON, EDWIN KERRY · 2005 to 2016
$4.0M
Adenosine in Renal Sympathetic NeurotransmissionR01DK091190 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JACKSON, EDWIN KERRY · 2011 to 2020
$3.4M
Howard Hughes Medical InstituteNHLBI NIH HHS R01 HL069846NHLBI NIH HHS R01 HL109002NIDDK NIH HHS P30 DK079307NIDDK NIH HHS R01 DK068575NIDDK NIH HHS R01 DK091190
6 · The paper itself

Abstract

The preglomerular microcirculation of spontaneously hypertensive rats (SHR) is hypersensitive to angiotensin (ANG) II, and studies have shown that this is likely due to enhanced coincident signaling between G protein subunits α

Indexed as

Angiotensin IIAnimalsCell MembraneCells, CulturedDisease Models, AnimalGTP-Binding Protein beta SubunitsGTP-Binding Protein gamma SubunitsGTP-Binding ProteinsHypertensionJuxtaglomerular ApparatusMaleMicrovesselsMuscle, Smooth, VascularMyocytes, Smooth MuscleNeuropeptide YPhospholipase C betaAngiotensin IIG-protein Beta gammaGTP-Binding Protein beta SubunitsGTP-Binding Protein gamma SubunitsGTP-Binding ProteinsNeuropeptide YPhospholipase C betaPlcb3 protein, ratRACK1 protein, ratReceptors for Activated C KinaseVasoconstrictor AgentsangiotensinhypertensionkidneyRACK1signal transduction

Identifiers

PMID28100502
PMCPMC5407068
OpenAlexW2574069592

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.