Evidence map›Paper›PMID 28102463›Full record

ArticlePathology oncology research : POR2017

Marked Differences of Haplotype Tagging SNP Distribution, Linkage, and Haplotype Profile of APOA5 Gene in Roma Population Samples.

Katalin Sumegi, Balazs Duga, Bela I Melegh, Zsolt Banfai, Erzsebet Kovesdi, Anita Maasz, Bela Melegh

Abstract read
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In one paragraph

Article in Pathology oncology research : POR, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Sequence Analysis ofFrontiers in genetics · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Katalin SumegiDepartment of Medical Genetics, Clinical Center, University of Pecs, Hungary, Szigeti Street 12, Pecs, H-7624, Hungary.
Balazs DugaDepartment of Medical Genetics, Clinical Center, University of Pecs, Hungary, Szigeti Street 12, Pecs, H-7624, Hungary.
Bela I MeleghDepartment of Medical Genetics, Clinical Center, University of Pecs, Hungary, Szigeti Street 12, Pecs, H-7624, Hungary.
Zsolt BanfaiDepartment of Medical Genetics, Clinical Center, University of Pecs, Hungary, Szigeti Street 12, Pecs, H-7624, Hungary.
Erzsebet KovesdiDepartment of Medical Genetics, Clinical Center, University of Pecs, Hungary, Szigeti Street 12, Pecs, H-7624, Hungary.
Anita MaaszDepartment of Medical Genetics, Clinical Center, University of Pecs, Hungary, Szigeti Street 12, Pecs, H-7624, Hungary.
Bela MeleghDepartment of Medical Genetics, Clinical Center, University of Pecs, Hungary, Szigeti Street 12, Pecs, H-7624, Hungary. melegh.bela@pte.hu.
University of Pecs · HU

Funding

OTKA K103983
6 · The paper itself

Abstract

Roma people are underprivileged, neglected population worldwide, with severe healthcare problems. They have significantly increased prevalence of cardiovascular morbidity, presumably related to their poor social status, alcohol consumption and smoking habits. Assuming that genetic background also plays a role in their susceptibility for cardiovascular diseases, we hypothesized that APOA5 gene polymorphisms, an important role-player in lipid metabolism and in the development of metabolic syndrome and cardio/cerebrovascular events, may also be involved. We examined four APOA5 polymorphisms in 363 Roma and 404 Hungarian DNA samples. For rs662799, rs2266788, rs207560 and rs3135506 we found elevated plasma triglyceride levels in the risk allele carriers compared to non-carriers in both populations. At least a two-fold significant increase was detected in minor allele frequencies in Roma when compared to Hungarians, except the rs2266788 variant. Haplotype analysis revealed significant increase of APOA5*2, APOA5*4 in Roma, as opposed to the higher levels of APOA5*5 found in Hungarians. Different linkage disequilibrium was found between rs207560 and rs3135506 variants in Roma compared to Hungarians. The profound differences observed in almost all APOA5 polymorphisms in Roma require special attention, since these variants are known to associate with cardio/cerebrovascular susceptibility.

Indexed as

AdultApolipoprotein A-VCardiovascular DiseasesFemaleGenetic Predisposition to DiseaseHaplotypesHumansHungaryLinkage DisequilibriumMaleMiddle AgedPolymorphism, Single NucleotideRomani PeopleAPOA5 protein, humanApolipoprotein A-VAPOA5HaplotypeLinkage disequilibriumRomaTriglyceride

Identifiers

PMID28102463
OpenAlexW2571743830

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.