ArticleBrain imaging and behavior2018
Alteration of gray matter microstructure in schizophrenia.
Article in Brain imaging and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Deep learning-based Desikan-Killiany parcellation of the brain using diffusion MRI.Scientific reports · 2026Article
- Review
- DDEvENet: Evidence-based ensemble learning for uncertainty-aware brain parcellation using diffusion MRI.Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society · 2025Article
- Matrix metalloproteinase 9 (MMP-9) activity, hippocampal extracellular free water, and cognitive deficits are associated with each other in early phase psychosis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- DDParcel: Deep Learning Anatomical Brain Parcellation From Diffusion MRI.IEEE transactions on medical imaging · 2024Article
- Functional-structural decoupling in visual network is associated with cognitive decline in patients with type 2 diabetes mellitus: evidence from a multimodal MRI analysis.Brain imaging and behavior · 2024Article
- Article
- Chromatic fusion: Generative multimodal neuroimaging data fusion provides multi-informed insights into schizophrenia.Human brain mapping · 2023Article
- Chromatic fusion: generative multimodal neuroimaging data fusion provides multi-informed insights into schizophrenia.medRxiv : the preprint server for health sciences · 2023Article
- Investigating the contribution of cytoarchitecture to diffusion MRI measures in gray matter using histology.Frontiers in neuroimaging · 2022Article
- Kynurenine pathway metabolites are associated with gray matter volume in subjects with schizophrenia.Frontiers in psychiatry · 2022Article
- Mild Traumatic Brain Injury Results in Significant and Lasting Cortical Demyelination.Frontiers in neurology · 2022Article
- Quantifying Genetic and Environmental Influence on Gray Matter Microstructure Using Diffusion MRI.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Mild traumatic brain injury impacts associations between limbic system microstructure and post-traumatic stress disorder symptomatology.NeuroImage. Clinical · 2020Article
- Diffusion kurtosis imaging of gray matter in schizophrenia.Cortex; a journal devoted to the study of the nervous system and behavior · 2019Article
- Article
Corrections and comments
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Authors and funding
15 authors at 9 institutions in 2 countries.
Funding
Abstract
Neuroimaging studies demonstrate gray matter (GM) macrostructural abnormalities in patients with schizophrenia (SCZ). While ex-vivo and genetic studies suggest cellular pathology associated with abnormal neurodevelopmental processes in SCZ, few in-vivo measures have been proposed to target microstructural GM organization. Here, we use diffusion heterogeneity- to study GM microstructure in SCZ. Structural and diffusion magnetic resonance imaging (MRI) were acquired on a 3 Tesla scanner in 46 patients with SCZ and 37 matched healthy controls (HC). After correction for free water, diffusion heterogeneity as well as commonly used diffusion measures FA and MD and volume were calculated for the four cortical lobes on each hemisphere, and compared between groups. Patients with early course SCZ exhibited higher diffusion heterogeneity in the GM of the frontal lobes compared to controls. Diffusion heterogeneity of the frontal lobe showed excellent discrimination between patients and HC, while none of the commonly used diffusion measures such as FA or MD did. Higher diffusion heterogeneity in the frontal lobes in early SCZ may be due to abnormal brain maturation (migration, pruning) before and during adolescence and early adulthood. Further studies are needed to investigate the role of heterogeneity as potential biomarker for SCZ risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.