Evidence map›Paper›PMID 28105243›Full record

ArticleOncology letters2016

Detection of aberrant methylated SEPT9 and NTRK3 genes in sporadic colorectal cancer patients as a potential diagnostic biomarker.

Shahin Behrouz Sharif, Shahriar Hashemzadeh, Reza Mousavi Ardehaie, Amirtaher Eftekharsadat, Mortaza Ghojazadeh, Amir Hossein Mehrtash, Mehrdad Asghari Estiar, Ladan Teimoori-Toolabi, Ebrahim Sakhinia

Open access · diamondAbstract read
In one paragraph

Article in Oncology letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Diagnostic Value and Clinical Significance of Methylated SEPT9 for Colorectal Cancer: A Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2019
    Pooled it
  2. Review
  3. Novel Diagnostic Biomarkers in Colorectal Cancer.International journal of molecular sciences · 2022
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. TheJournal of thoracic disease · 2019
    Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Shahin Behrouz SharifDepartment of Biochemistry and Clinical Laboratory, Division of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz 5165665811, Iran; Department of Molecular Medicine, Pasteur Institute of Iran, Tehran 1316943551, Iran; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz 5166614731, Iran.
Shahriar HashemzadehDepartment of General & Vascular Surgery, Tabriz University of Medical Sciences, Tabriz 5165665811, Iran; Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz 5165665811, Iran.
Reza Mousavi ArdehaieDepartment of Biochemistry and Clinical Laboratory, Division of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz 5165665811, Iran; Department of Molecular Medicine, Pasteur Institute of Iran, Tehran 1316943551, Iran.
Amirtaher EftekharsadatDepartment of Pathology, Imam Reza Hospital, Tabriz University of Medical Sciences, Tabriz 5165665811, Iran.
Mortaza GhojazadehLiver and Gastrointestinal Disease Research Center and Department of General and Thoracic Surgery, Tabriz University of Medical Sciences, Tabriz 5165665811, Iran.
Amir Hossein MehrtashDepartment of Molecular Medicine, Pasteur Institute of Iran, Tehran 1316943551, Iran.
Mehrdad Asghari EstiarDepartment of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran 1471613151, Iran.
Ladan Teimoori-ToolabiDepartment of Molecular Medicine, Pasteur Institute of Iran, Tehran 1316943551, Iran.
Ebrahim SakhiniaDepartment of Biochemistry and Clinical Laboratory, Division of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz 5165665811, Iran; Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz 5165665811, Iran.
Tabriz University of Medical Sciences · IRPasteur Institute of Iran · IRImam Reza Hospital · IRTehran University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC) is one of the most common malignancies, and the third leading cause of cancer mortality worldwide. Timely detection of CRC in patients with earlier stages provides the highest rate of survival. Epigenetic alterations are important in the occurrence and progression of CRC, and represent the primary modifications of cancer cells. Therefore, detection of these alterations in CRC cases are thought to hold great promise as diagnostic biomarkers. It has been shown that the

Indexed as

biomarkercolorectal cancermethylationNTRK3SEPT9

Identifiers

PMID28105243
PMCPMC5228494
OpenAlexW2544767537

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.