Evidence map›Paper›PMID 28115480›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017

Sexual Dimorphism in a Reciprocal Interaction of Ryanodine and IP

Eugen V Khomula, Luiz F Ferrari, Dionéia Araldi, Jon D Levine

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 46 citations in OpenAlex.

  1. Sex differences in the transition to chronic pain.The Journal of clinical investigation · 2025
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Developmental mechanisms of CPSP: Clinical observations and translational laboratory evaluations.Canadian journal of pain = Revue canadienne de la douleur · 2022
    Review
  10. Article
  11. Article
  12. Review
  13. Opioid-Induced Hyperalgesic Priming in Single Nociceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  14. Review
  15. Article
  16. Mechanisms Mediating High-Molecular-Weight Hyaluronan-Induced Antihyperalgesia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
    Article
  17. Article
  18. Article
  19. The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019
    Article
  20. Role of Nociceptor Toll-like Receptor 4 (TLR4) in Opioid-Induced Hyperalgesia and Hyperalgesic Priming.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Eugen V KhomulaDepartments of Medicine and Oral Surgery, and Division of Neuroscience, University of California, San Francisco, San Francisco, California 94143.ORCID 0000-0003-0221-2237
Luiz F FerrariDepartments of Medicine and Oral Surgery, and Division of Neuroscience, University of California, San Francisco, San Francisco, California 94143.
Dionéia AraldiDepartments of Medicine and Oral Surgery, and Division of Neuroscience, University of California, San Francisco, San Francisco, California 94143.ORCID 0000-0001-8379-2901
Jon D LevineDepartments of Medicine and Oral Surgery, and Division of Neuroscience, University of California, San Francisco, San Francisco, California 94143 Jon.Levine@ucsf.edu.ORCID 0000-0003-0681-5545
University of California, San Francisco · US

Funding

Nociceptor mechanisms in the transition from acute to chronic painR01NS084545 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEVINE, JON DAVID · 2014 to 2018
$3.1M
NINDS NIH HHS R01 NS084545
6 · The paper itself

Abstract

Hyperalgesic priming, a model of pain chronification in the rat, is mediated by ryanodine receptor-dependent calcium release. Although ryanodine induces priming in both sexes, females are 5 orders of magnitude more sensitive, by an estrogen receptor α (EsRα)-dependent mechanism. An inositol 1,4,5-triphosphate (IP

Indexed as

Sex CharacteristicsAnimalsCells, CulturedDinoprostoneDisease Models, AnimalEnzyme InhibitorsFemaleGanglia, SpinalHyperalgesiaInositol 1,4,5-TrisphosphateInositol 1,4,5-Trisphosphate ReceptorsMacrocyclic CompoundsMaleOligodeoxyribonucleotides, AntisenseOxazolesPain MeasurementDinoprostoneEnzyme InhibitorsInositol 1,4,5-TrisphosphateInositol 1,4,5-Trisphosphate ReceptorsMacrocyclic CompoundsOligodeoxyribonucleotides, AntisenseOxazolesRyanodineRyanodine Receptor Calcium Release ChannelThapsigarginxestospongin Cendoplasmic reticulumhyperalgesiahyperalgesic primingIP3 receptornociceptorryanodine receptor

Identifiers

PMID28115480
PMCPMC5338754
OpenAlexW2581845099

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.