Evidence map›Paper›PMID 28119443›Full record

ArticleJournal of lipid research2017

Measuring niacin-associated skin toxicity (NASTy) stigmata along with symptoms to aid development of niacin mimetics.

Richard L Dunbar, Harsh Goel, Sony Tuteja, Wen-Liang Song, Grace Nathanson, Zeeshan Babar, Dusanka Lalic, Joel M Gelfand, Daniel J Rader, Gary L Grove

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of lipid research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Richard L DunbarUniversity of Pennsylvania Institute for Translational Medicine and Therapeutics, Philadelphia PA; Department of Medicine, Division of Cardiovascular Medicine, University of Pennsylvania Medical Center, Philadelphia, PA; Department of Medicine, Division of Translational Medicine and Human Genetics, University of Pennsylvania Medical Center, Philadelphia, PA. Electronic address: richard.dunbar@uphs.upenn.edu.
Harsh GoelDepartment Medicine, York Hospital, York, PA.
Sony TutejaDepartment of Medicine, Division of Translational Medicine and Human Genetics, University of Pennsylvania Medical Center, Philadelphia, PA.
Wen-Liang SongDepartment of Medicine, Division of Cardiovascular Medicine, Vanderbilt University, Nashville, TN.
Grace NathansonUniversity of Pennsylvania Institute for Translational Medicine and Therapeutics, Philadelphia PA.
Zeeshan BabarHUMC Mountainside Hospital, Montclair, NJ.
Dusanka LalicUniversity of Pennsylvania Institute for Translational Medicine and Therapeutics, Philadelphia PA; Department of Medicine, Division of Translational Medicine and Human Genetics, University of Pennsylvania Medical Center, Philadelphia, PA.
Joel M GelfandUniversity of Pennsylvania Institute for Translational Medicine and Therapeutics, Philadelphia PA; Departments of Dermatology and Biostatistics and Epidemiology, and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA.
Daniel J RaderUniversity of Pennsylvania Institute for Translational Medicine and Therapeutics, Philadelphia PA; Department of Medicine, Division of Cardiovascular Medicine, University of Pennsylvania Medical Center, Philadelphia, PA; Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, and Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, PA; Department of Medicine, Division of Translational Medicine and Human Genetics, University of Pennsylvania Medical Center, Philadelphia, PA.
Gary L GrovecyberDERM, Inc., Broomall, PA.

Funding

INSTITUTIONAL CLINICAL AND TRANSLATIONAL SCIENCE AWARDUL1RR024134 · NCRR · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2006 to 2011
$70.4M
The Nicotinic Acid Receptor HM74A in Vascular InjuryP50HL083799 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2006 to 2010
$15.8M
Mentored Career Development in Patient Oriented ResearchK12RR017625 · NCRR · UNIVERSITY OF PENNSYLVANIA · PI RADER, DANIEL JAMES · 2002 to 2006
$4.1M
Niacin's effect on fatty acids and inflammatory markers (NEFA-IM)K23HL091130 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI DUNBAR, RICHARD LOUIS · 2009 to 2012
$569k
NCRR NIH HHS K12 RR017625NCRR NIH HHS UL1 RR024134NHLBI NIH HHS K23 HL091130NHLBI NIH HHS P50 HL083799
6 · The paper itself

Abstract

Though cardioprotective, niacin monotherapy is limited by unpleasant cutaneous symptoms mimicking dermatitis: niacin-associated skin toxicity (NASTy). Niacin is prototypical of several emerging drugs suffering off-target rubefacient properties whereby agonizing the GPR109A receptor on cutaneous immune cells provokes vasodilation, prompting skin plethora and

Indexed as

BiomimeticsColorimetryDose-Response Relationship, DrugDrug-Related Side Effects and Adverse ReactionsDyslipidemiasFlushingHumansHypolipidemic AgentsIrritantsLaser-Doppler FlowmetryNiacinReceptors, G-Protein-CoupledReceptors, NicotinicSkinVasodilationHCAR2 protein, humanHypolipidemic AgentsIrritantsNiacinReceptors, G-Protein-CoupledReceptors, Nicotinicdyslipidemiaflushinghypolipidemic drugslaser Doppler flowmetryniacin-associated skin toxicityquantitationwhite-light spectroscopy

Identifiers

PMID28119443
PMCPMC5392735

What Socratic holds

Texttitle and abstract
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.