← GLP-1 receptor agonists × blood pressure

TrialJournal of hypertension2017

Effects of the glucagon-like peptide-1 receptor agonist liraglutide on 24-h ambulatory blood pressure in patients with type 2 diabetes and stable coronary artery disease: a randomized, double-blind, placebo-controlled, crossover study.

Preman Kumarathurai et al.PubMed ↗Publisher ↗

  • Liraglutidelooks bad hereHigher evening SBP, higher evening DBP, no clear effect on 24-h SBP.Randomised, small.

What the trial testedrandomised · 2017

Randomised vs placebo

Probably raised evening SBP

+9.20mmHg+1.10 to +17.2

liraglutide vs placebo

As reported

difference 9.2 mmHg, 95% CI 1.10–17.2

Randomised vs placebo

Probably raised evening DBP

+9.70mmHg+3.90 to +15.5

liraglutide vs placebo

As reported

difference 9.7 mmHg, 95% CI 3.90–15.5

Range includes no effect

No clear effect on 24-h SBP

+1.80mmHg−4.33 to +7.93

liraglutide vs placebo

As reported

difference 1.8 mmHg, 95% CI −4.33 to 7.93 · the paper's word: mean 24-h SBP

Range includes no effect

No clear effect on 24-h DBP

+4.20mmHg−0.74 to +9.17

liraglutide vs placebo

As reported

difference 4.2 mmHg, 95% CI −0.74 to 9.17 · the paper's word: mean 24-h DBP

+1 more in the walkthrough ↓

Who was studied, and how

people with hypertension, in this paper

The trial randomly assignedassigned by chance

liraglutide
placebo

Probably raised evening SBP+9.20

Probably raised evening DBP+9.70

No clear effect on 24-h SBP+1.80

randomised

the abstract, start to end

… changes in mean 24-h SBP [difference +1.8 mmHg (95% confidence interval, 95% CI: -4.33 to 7.93)] or DBP [+4.2 mmHg (-0.74 to 9.17)].

… for increase in evening SBP and DBP [+9.2 mmHg (95% CI: 1.1-17.2) and +9.7 mmHg (95% CI: 3.9-15.5), …

… increased after liraglutide [+7.6 bpm (95% CI: 2.56-12.62)].

← favours treatmentfavours comparator →
could be chance
Mean 24-h SBPliraglutide vs placebo
1.8−4.33 to 7.93
Mean 24-h DBPliraglutide vs placebo
4.2−0.74 to 9.17
Evening SBPliraglutide vs placebo
9.21.10–17.2
Evening DBPliraglutide vs placebo
9.73.90–15.5
Mean heart rateliraglutide vs placebo
7.62.56–12.6
GLP-1 receptor agonistsBlood pressureAdverse events & safety

GLP-1 receptor agonists × blood pressurehelps?mixed

unlikelylikely
0.500.50 without it
← favours treatmentfavours comparator →
this papermore certainless certain
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18 papers cite it

2017
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Full record →Abstract, authors, funding and every citing paper · PMID 28129251