Evidence map›Paper›PMID 28130879›Full record

ArticleMolecular nutrition & food research2017

Variations in dietary intake and plasma concentrations of plant sterols across plant-based diets among North American adults.

Karen Jaceldo-Siegl, Dieter Lütjohann, Rawiwan Sirirat, Andrew Mashchak, Gary E Fraser, Ella Haddad

Open access · greenAbstract read
In one paragraph

Article in Molecular nutrition & food research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Review
  6. Review
  7. Aspects of β-sitosterol's Pharmacology, Nutrition and Analysis.Current pharmaceutical biotechnology · 2025
    Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Karen Jaceldo-SieglAdventist Health Studies, School of Public Health, Loma Linda University, Loma Linda, CA, USA.
Dieter LütjohannInstitute of Clinical Chemistry and Clinical Pharmacology, University Clinics of Bonn, Bonn.
Rawiwan SiriratAdventist Health Studies, School of Public Health, Loma Linda University, Loma Linda, CA, USA.
Andrew MashchakAdventist Health Studies, School of Public Health, Loma Linda University, Loma Linda, CA, USA.
Gary E FraserAdventist Health Studies, School of Public Health, Loma Linda University, Loma Linda, CA, USA.
Ella HaddadAdventist Health Studies, School of Public Health, Loma Linda University, Loma Linda, CA, USA.
Loma Linda University Health Care · USLoma Linda University · USUniversity Hospital Bonn · DE

Funding

Plant-based diets and risk of cancerU01CA152939 · NCI · LOMA LINDA UNIVERSITY · PI FRASER, GARY E. · 2011 to 2015
$5.7M
NCI NIH HHS U01 CA152939
6 · The paper itself

Abstract

scopePhytosterols are bioactive compounds in plants with similar cholesterol-lowering properties as vegetarian diets. However, information on phytosterol intake and plasma plant sterols among vegetarians is sparse. METHODS AND

resultsWe examined dietary intake and plasma concentration of plant sterols and cholesterol across five dietary patterns in the Adventist Health Study-2 Calibration Sub-study (n = 861, 66% females, average age 61 years). To measure intake and plasma concentrations of these compounds, we used 24-h dietary recalls and gas-liquid chromatography-flame ionization detection, respectively. Mean (SD) total phytosterol and cholesterol intake were 363 (176) mg/day and 131 (111) mg/day; plasma β-sitosterol, campesterol, and cholesterol were 3.3 (1.7) μg/mL, 4.2 (2.3) μg/mL, and 1.9 (0.4) mg/mL, respectively. Total phytosterol intake was lowest among non-vegetarians (263 mg/day) and highest among vegans (428 mg/day) (p < 0.0001). Cholesterol intake was lowest among vegans (15.2 mg/day) and highest among non-vegetarians (124.6 mg/day) (p < 0.0001). Plasma plant sterols and cholesterol did not differ by diet. Cholesterol-adjusted plasma β-sitosterol and campesterol were significantly higher in Blacks than Whites, though no ethnic differences were observed in dietary intake of these plant sterols.

conclusionDietary intake but not plasma concentration of plant sterols and cholesterol varies across distinct plant-based diets.

Indexed as

DietAgedCholesterolCross-Sectional StudiesDiet, VegetarianFemaleHumansMaleMiddle AgedNorth AmericaNutrition SurveysPhytosterolsSitosterolscampesterolCholesterolgamma-sitosterolPhytosterolsSitosterolsBeta-sitosterolCampesterolCholesterolPhytosterolsVegetarian

Identifiers

PMID28130879
PMCPMC5533645
OpenAlexW2580797122

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.