Evidence mapPaperPMID 28138803Full record

Observational studyAdvances in therapy2017

Effectiveness and Persistence of Liraglutide Treatment Among Patients with Type 2 Diabetes Treated in Primary Care and Specialist Settings: A Subgroup Analysis from the EVIDENCE Study, a Prospective, 2-Year Follow-up, Observational, Post-Marketing Study.

Luc Martinez, Alfred Penfornis, Jean-Francois Gautier, Eveline Eschwège, Guillaume Charpentier, Amira Bouzidi, Pierre Gourdy

Registry-linked trialOpen access · hybridAbstract readObservational Study
In one paragraph

Observational study in Advances in therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT01226966. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01226966 completed

Conditions for Prescribing Liraglutide in Medical Practice and Assessment of Maintenance Level, Tolerability, and Efficacy of Victoza® (Liraglutide) in Subjects With Type 2 Diabetes

Ran2010Enrolled3,152Registered outcomes16Posted comparisons0ConditionsDiabetes, Diabetes Mellitus, Type 2Armsliraglutide
PMID 26424330other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2022
    Guideline
  2. Article
  3. Article
  4. Review
  5. Article
  6. A Retrospective Database Study of Liraglutide Persistence Associated with Glycemic and Body Weight Control in Patients with Type 2 Diabetes.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2019
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Luc MartinezUniversité Pierre and Marie Curie, Paris, France.
Alfred PenfornisCentre Hospitalier Sud Francilien, Corbeil-Essonnes, France.
Jean-Francois GautierHôpital Lariboisière, Paris, France.
Eveline EschwègeINSERM, Villejuif, France.
Guillaume CharpentierCentre Hospitalier Sud Francilien, Corbeil-Essonnes, France.
Amira BouzidiNovo Nordisk, Paris, France.
Pierre GourdyService de Diabétologie, maladies Métaboliques et Nutrition, Centre Hospitalier Universitaire de Toulouse, Université de Toulouse, Toulouse, France. pierre.gourdy@inserm.fr.
Centre Hospitalier Sud Francilien · FRHôpital Lariboisière · FRInserm · FRSorbonne Université · FRUniversité de Toulouse · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe objective of this subgroup analysis is to investigate the effectiveness of liraglutide in people with type 2 diabetes (T2D) treated within the primary care physician (PCP) and specialist care settings.

methodsEVIDENCE is a prospective, observational study of 3152 adults with T2D recently starting or about to start liraglutide treatment in France. We followed patients in the PCP and specialist settings for 2 years to evaluate the effectiveness of liraglutide in glycemic control and body weight reduction. Furthermore, we evaluated the changes in combined antihyperglycemic treatments, the reasons for prescribing liraglutide, patient satisfaction, and safety of liraglutide in these two treatment settings.

resultsAfter 2 years of follow-up, 477 out of 1209 (39.0%) of PCP and 297 out of 1398 (21.2%) of specialist-treated patients still used liraglutide and maintained the glycated hemoglobin (HbA

conclusionDespite differences in demography and clinical characteristics of patients treated for T2D in PCP and specialty care, greater reduction in HbA

trial registrationClinicalTrials.gov identifier, NCT01226966.

fundingNovo Nordisk A/S.

Indexed as

Diabetes Mellitus, Type 2LiraglutideMedicinePrimary Health CareAdultFemaleFollow-Up StudiesFranceGlycated HemoglobinHumansHypoglycemic AgentsMaleMedication AdherenceMedication Therapy ManagementMiddle AgedPatient SatisfactionGlycated HemoglobinHypoglycemic AgentsLiraglutideGLP-1 receptor agonistLiraglutideObservational studyPrimary careType 2 diabetesWeight management

Identifiers

PMID28138803
PMCPMC5350193
OpenAlexW2582486031

What Socratic holds

Texttitle and abstract
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.