Trial reportJournal of the Royal Society, Interface2017
Oscillatory wall shear stress is a dominant flow characteristic affecting lesion progression patterns and plaque vulnerability in patients with coronary artery disease.
Trial report in Journal of the Royal Society, Interface, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it.
- High Coronary Wall Shear Stress Worsens Plaque Vulnerability: A Systematic Review and Meta-Analysis.Angiology · 2021Pooled it
- Prediction of Long Term Restenosis Risk After Surgery in the Carotid Bifurcation by Hemodynamic and Geometric Analysis.Annals of biomedical engineering · 2019Trial
- Disentangling the Hemodynamic Effects of A-Wave Loss and Cardiac Output Reduction in Atrial Fibrillation.Annals of biomedical engineering · 2026Article
- Hemodynamic Effects of Aortic Stenosis on Coronary Flow Dynamics.Annals of biomedical engineering · 2026Article
- Explainable ML for ACS culprit plaques: a multidimensional CCTA model highlighting hemodynamic increment.The international journal of cardiovascular imaging · 2026Article
- History and emerging trends of computational fluid dynamics applications in atherosclerosis: a bibliometric analysis and narrative review.Annals of medicine and surgery (2012) · 2026Review
- Biomechanics of Plaque Rupture and Cardiovascular Calcification.Advances in experimental medicine and biology · 2026Review
- Evaluation of subclinical atherosclerosis in women with polycystic ovary syndrome based on ultra-high-frequency ultrasound and vector flow imaging.Quantitative imaging in medicine and surgery · 2025Article
- A systematic evaluation of the impact of contralateral stenosis on ipsilateral internal carotid artery hemodynamics using computational fluid dynamics.Quantitative imaging in medicine and surgery · 2025Article
- High-intensity helical flow: a double-edged sword in coronary artery haemodynamics.Royal Society open science · 2025Article
- Pulsatile low shear stress increases susceptibility to endothelial inflammation via upregulation of IFT and activation of YAP.APL bioengineering · 2025Article
- Maximum admittance method for cerebrovascular outlet boundary conditions and importance of stenosis severity as a dominant factor on hemodynamics.Scientific reports · 2025Article
- Bridging hemodynamics, tissue mechanics, and pathophysiology in coronary artery disease: A new agent-based model with tetrahedral mesh integration.Journal of biomechanics · 2025Article
- Anatomical location-related hemodynamic variations are associated with atherosclerosis in the middle cerebral artery: a preliminary cross-sectional 4D flow and 3D vessel wall MRI study.Quantitative imaging in medicine and surgery · 2025Article
- The application of computational fluid dynamics in hepatic portal vein haemodynamics research: a narrative review.Quantitative imaging in medicine and surgery · 2025Review
- Hemodynamic disturbance and mTORC1 activation: Unveiling the biomechanical pathogenesis of thoracic aortic aneurysms in Marfan syndrome.Journal of pharmaceutical analysis · 2025Article
- Article
- Patient-Specific Numerical Simulations of Coronary Artery Hemodynamics and Biomechanics: A Pathway to Clinical Use.Cardiovascular engineering and technology · 2024Review
- Advances in the Computational Assessment of Disturbed Coronary Flow and Wall Shear Stress: A Contemporary Review.Journal of the American Heart Association · 2024Review
- A new understanding of coronary curvature and haemodynamic impact on the course of plaque onset and progression.Royal Society open science · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although experimental studies suggest that low and oscillatory wall shear stress (WSS) promotes plaque transformation to a more vulnerable phenotype, this relationship has not been examined in human atherosclerosis progression. Thus, the aim of this investigation was to examine the association between oscillatory WSS, in combination with WSS magnitude, and coronary atherosclerosis progression. We hypothesized that regions of low and oscillatory WSS will demonstrate progression towards more vulnerable lesions, while regions exposed to low and non-oscillatory WSS will exhibit progression towards more stable lesions. Patients (n = 20) with non-flow-limiting coronary artery disease (CAD) underwent baseline and six-month follow-up angiography, Doppler velocity and radiofrequency intravascular ultrasound (VH-IVUS) acquisition. Computational fluid dynamics models were constructed to compute time-averaged WSS magnitude and oscillatory WSS. Changes in VH-IVUS-defined total plaque and constituent areas were quantified in focal regions (i.e. sectors; n = 14 235) and compared across haemodynamic categories. Compared with sectors exposed to low WSS magnitude, high WSS sectors demonstrated regression of total plaque area (p < 0.001) and fibrous tissue (p < 0.001), and similar progression of necrotic core. Sectors subjected to low and oscillatory WSS exhibited total plaque area regression, while low and non-oscillatory WSS sectors demonstrated total plaque progression (p < 0.001). Furthermore, compared with low and non-oscillatory WSS areas, sectors exposed to low and oscillatory WSS demonstrated regression of fibrous (p < 0.001) and fibrofatty (p < 0.001) tissue and similar progression of necrotic core (p = 0.82) and dense calcium (p = 0.40). Herein, we demonstrate that, in patients with non-obstructive CAD, sectors subjected to low and oscillatory WSS demonstrated regression of total plaque, fibrous and fibrofatty tissue, and progression of necrotic core and dense calcium, which suggest a transformation to a more vulnerable phenotype.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.