Antihypertensives × blood pressure

Observational studyHigh blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension2017

Impact of Statin Therapy on the Blood Pressure-Lowering Efficacy of a Single-Pill Perindopril/Amlodipine Combination in Hypertensive Patients with Hypercholesterolemia.

Yuriy Sirenko et al.PubMed ↗Publisher ↗

  • Statin [+] grouplooks bad hereHigher BP control.Correlation only, not a test of it.

What moved togetherboth groups pooled, not the treatment’s effect

Correlation, not cause

Statin [+] group went with higher BP control

+14.0percentage points

statin [+] group vs statin [-] group, in patients with concomitant hypertension and hypercholesterolemia

As reported

difference 14 %, no interval

+8 more in the walkthrough ↓

Who was studied, and how

732people with hypertension, in this paper

Already taking statin [+] group, or nottheir own situation, not assigned

on statin [+] group
statin [-] group

Statin [+] group went with higher BP control+14.0

correlation, not a test

the abstract, start to end

[-] group: 73 vs 64% respectively (+14%, P < 0.05).

(n = 93), or triple therapy (n = 18): -38.8/-20.0, -39.1/-20.1, -38.0/-19.4, -39.9/-18.3 mmHg respectively (P < 0.001 vs

← favours treatmentfavours comparator →
could be chance
No interval given · direction only, strength unknown
BP control (<140/90 mmHg)statin [+] group vs statin [-] group, in patients with concomitant hypertension and hypercholesterolemia
14
BP reduction (systolic/diastolic)perindopril/amlodipine vs baseline, in statin [+] group, previously untreated (n = 18)
−38.8
BP reduction (systolic/diastolic)perindopril/amlodipine vs baseline, in statin [+] group, previously untreated (n = 18)
−20.0
BP reduction (systolic/diastolic)perindopril/amlodipine vs baseline, in statin [+] group, treated with monotherapy (n = 97)
−39.1
BP reduction (systolic/diastolic)perindopril/amlodipine vs baseline, in statin [+] group, treated with monotherapy (n = 97)
−20.1
BP reduction (systolic/diastolic)perindopril/amlodipine vs baseline, in statin [+] group, treated with dual therapy (n = 93)
−38.0
BP reduction (systolic/diastolic)perindopril/amlodipine vs baseline, in statin [+] group, treated with dual therapy (n = 93)
−19.4
BP reduction (systolic/diastolic)perindopril/amlodipine vs baseline, in statin [+] group, treated with triple therapy (n = 18)
−39.9
BP reduction (systolic/diastolic)perindopril/amlodipine vs baseline, in statin [+] group, treated with triple therapy (n = 18)
−18.3
StatinsAntihypertensivesBlood pressure
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