ArticleAddiction biology2018
Gray-matter relationships to diagnostic and transdiagnostic features of drug and behavioral addictions.
Article in Addiction biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 4 syntheses or guidelines pooled it, 107 citations in OpenAlex.
- Meta-Analysis of Structural and Functional Brain Abnormalities in Cocaine Addiction.Frontiers in psychiatry · 2022Pooled it
- Shared gray matter alterations in subtypes of addiction: a voxel-wise meta-analysis.Psychopharmacology · 2021Pooled it
- Common abnormality of gray matter integrity in substance use disorder and obsessive-compulsive disorder: A comparative voxel-based meta-analysis.Human brain mapping · 2021Pooled it
- Shared gray matter alterations in individuals with diverse behavioral addictions: A voxel-wise meta-analysis.Journal of behavioral addictions · 2020Pooled it
- Impulsivity and neuroticism share distinct functional connectivity signatures with alcohol-use risk in youth.Molecular psychiatry · 2026Article
- The neural vulnerabilities in reward processing in gambling disorder.Journal of behavioral addictions · 2025Article
- Distinct patterns of hippocampal subfield volumes predict coping strategies, emotion regulation, and impulsivity in healthy adults.Brain imaging and behavior · 2024Article
- Frontal white and gray matter abnormality in gambling disorder: A multimodal MRI study.Journal of behavioral addictions · 2024Article
- Cocaine self-administration behavior is associated with subcortical and cortical morphometry measures in individuals with cocaine use disorder.The American journal of drug and alcohol abuse · 2024Article
- Neural mechanisms linked to treatment outcomes and recovery in substance-related and addictive disorders.Dialogues in clinical neuroscience · 2023Review
- Common and distinct fronto-striatal volumetric changes in heroin and cocaine use disorders.Brain : a journal of neurology · 2023Article
- Associations between levels of Internet Gaming Disorder symptoms and striatal morphology-replication and associations with social anxiety.Psychoradiology · 2022Article
- The Potential of N-acetyl Cysteine in Behavioral Addictions and Related Compulsive and Impulsive Behaviors and Disorders: a Scoping Review.Current addiction reports · 2022Article
- Compulsive Sexual Behavior Disorder should not be classified by solely relying on component/symptomatic features •.Journal of behavioral addictions · 2022Article
- Rethinking "aggression" and impulsivity in bipolar disorder: Risk, clinical and brain circuitry features.Journal of affective disorders · 2022Article
- Lower prefrontal cortical synaptic vesicle binding in cocaine use disorder: An exploratoryAddiction biology · 2022Article
- The neurobiology of drug addiction: cross-species insights into the dysfunction and recovery of the prefrontal cortex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- Brain multimodal co-alterations related to delay discounting: a multimodal MRI fusion analysis in persons with and without cocaine use disorder.BMC neuroscience · 2021Article
- Machine learning approaches for parsing comorbidity/heterogeneity in antisociality and substance use disorders: A primer.Personality neuroscience · 2021Article
- Discrete Roles for Impulsivity and Compulsivity in Gambling Disorder.Frontiers in psychiatry · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Alterations in neural structure have been reported in both cocaine-use disorder and gambling disorder, separately, suggesting similarities across addiction diagnoses. Individual variation in neural structure has also been associated with impulsivity, a dimensional construct implicated in addictions. This study combines categorical (diagnosis-based) and dimensional (transdiagnostic) approaches to identify neural structural alterations linked to addiction subtypes and trait impulsivity, respectively, across individuals with gambling disorder (n = 35), individuals with cocaine-use disorder (n = 37) and healthy comparison individuals (n = 37). High-resolution T1-weighted data were analyzed using modulated voxel-based morphometry (VBM). Statistical analyses were conducted using whole-brain general-linear models, corrected for family-wise error (pFWE < .05). Categorical analyses indicated a main effect of diagnostic group on prefrontal (dorsal anterior cingulate and ventromedial prefrontal cortex) gray matter volumes (GMVs), involving decreased GMVs among cocaine-use disorder participants only. Dimensional analyses indicated a negative association between trait impulsivity and cortical (insula) and subcortical (amygdala and hippocampus) GMVs across all participants. Conjunction analysis indicated little anatomical overlap between regions identified as differentiating diagnostic groups and regions covarying with impulsivity. These data provide first evidence of neural structural differences between gambling disorder and an illicit substance-use disorder. They further indicate dissociable effects of diagnostic groupings and trait impulsivity on neural structure among individuals with behavioral and drug addictions. Study findings highlight the importance of considering both categorical and dimensional (e.g. Research Domain Criteria; RDoC) analysis approaches within the context of addictions research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.