Evidence map›Paper›PMID 28160545›Full record

Trial reportAging2017

Impact of resistance training on the autophagy-inflammation-apoptosis crosstalk in elderly subjects.

Yubisay Mejías-Peña, Brisamar Estébanez, Paula Rodriguez-Miguelez, Rodrigo Fernandez-Gonzalo, Mar Almar, José A de Paz, Javier González-Gallego, María J Cuevas

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Aging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07017517 (Effect of Physical Therapy on NLRP3 Inflammasome Activation and Muscle Atrophy in Critical Illness Myopathy), which is not on this map. Cited by 55 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 1 pooled it
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07017517 narecruitingnot on this mapstarted 2026, after this paper: background citation

Effect of Physical Therapy on NLRP3 Inflammasome Activation and Muscle Atrophy in Critical Illness Myopathy (PT-NLRP3-CIM).

TypeinterventionalSponsorUniversity of ChileRan2026 to 2027Enrolled24ConditionsCritical Illness MyopathyArmsMotomed Letto® servo-assisted cycling + standard physiotherapy, Standard physiotherapy
3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 1 synthesis or guideline pooled it, 98 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Yubisay Mejías-PeñaInstitute of Biomedicine (IBIOMED), University of León, León, Spain.
Brisamar EstébanezInstitute of Biomedicine (IBIOMED), University of León, León, Spain.
Paula Rodriguez-MiguelezDivision of Clinical Translational Science, Georgia Prevention Institute, Department of Pediatrics, Augusta University, Augusta, GA, USA.
Rodrigo Fernandez-GonzaloRadiobiology Unit, Laboratory of Molecular and Cellular Biology, Institute for Environment, Health and Safety, Belgian Nuclear Research Centre (SCK•CEN), Mol, Belgium.
Mar AlmarInstitute of Biomedicine (IBIOMED), University of León, León, Spain.
José A de PazInstitute of Biomedicine (IBIOMED), University of León, León, Spain.
Javier González-GallegoInstitute of Biomedicine (IBIOMED), University of León, León, Spain.
María J CuevasInstitute of Biomedicine (IBIOMED), University of León, León, Spain.
Universidad de León · ESBelgian Nuclear Research Centre · BEPrevention Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging is associated with a decline in autophagy and a state of low-grade inflammation which further affects apoptosis and autophagy. Importantly, these alterations could reverse with regular physical activity. This study assessed the effects of a resistance exercise training program on autophagy, NLRP3 inflammasome, and apoptosis in peripheral blood mononuclear cells (PBMCs) from old subjects. Twenty-six healthy women and men (age, 69.6±1.5 yr) were randomized to a training (TG) or a control (CG) group. TG performed an 8-week resistance training program, while CG followed their daily routines. Protein expression of beclin-1, Atg12, Atg16 and LAMP-2 increased following the training program, while expression of p62/SQSTM1 and phosphorylation of ULK-1 at Ser757 were significantly lower. Resistance exercise also induced a decrease in NLRP3 expression and in the caspase-1/procaspase-1 ratio. Expression of Bcl-2 and Bcl-xL, as well as the Bad/BcL-2 ratio were reduced, and there was a significant decrease in the protein content of caspase-3. The results obtained seem to indicate that 8-week resistance training stimulates autophagy, prevents NLRP3 inflammasome activation, and reduces apoptosis in PBMCs from elderly subjects. These data could have a significant impact in prevention and rehabilitation programs currently employed in elderly population.

Indexed as

Resistance TrainingAgedApoptosisAutophagyAutophagy-Related Protein 12Autophagy-Related ProteinsBeclin-1FemaleHumansInflammasomesInflammationLeukocytes, MononuclearLysosomal-Associated Membrane Protein 2MaleNLR Family, Pyrin Domain-Containing 3 ProteinATG12 protein, humanATG16L1 protein, humanAutophagy-Related Protein 12Autophagy-Related ProteinsBeclin-1InflammasomesLAMP2 protein, humanLysosomal-Associated Membrane Protein 2NLR Family, Pyrin Domain-Containing 3 Proteinapoptosisautophagyelderlyinflammasomeresistance exercise

Identifiers

PMID28160545
PMCPMC5361672
OpenAlexW2585287241

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.