Who was studied, and how
Three numbers in the abstract
Where each one falls
Where it lands on the map
What it changes
Among 21 other studies
people with heart failure, in this paper
The trial randomly assignedassigned by chance
statins
placebo
Probably lowered hospitalization for worsening heart failure−21%
No clear effect on sudden cardiac deaths−8%
No clear effect on deaths−12%
randomisedthe abstract, start to end
… in HF patients [relative risk (RR) 0.92, 95% confidence interval (CI) 0.70 to 1.21], all-cause mortality [RR 0.88, 95% CI 0.75 to 1.02] but significantly reduced hospitalization for worsening heart failure (HWHF) although modestly [RR 0.79, 95% CI 0.66 to 0.94].
← favours treatmentfavours comparator →
could be chanceSudden cardiac deathstatins vs placebo
RR 0.920.70–1.21
All-cause mortalitystatins vs placebo
RR 0.880.75–1.02
Hospitalization for worsening heart failurestatins vs placebo
RR 0.790.66–0.94
StatinsCardiovascular eventsAll-cause mortalityAdverse events & safety
Statins × cardiovascular eventshelps?replicated
unlikelylikely
0.86not counted
Statins × adverse events & safetyharms?mixed
unlikelylikely
0.16not counted
Statins × all-cause mortalityhelps?mixed
unlikelylikely
0.50not counted
← favours treatmentfavours comparator →
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