Evidence map›Paper›PMID 28174249›Full record

ArticleDevelopment (Cambridge, England)2017

Tracking the embryonic stem cell transition from ground state pluripotency.

Tüzer Kalkan, Nelly Olova, Mila Roode, Carla Mulas, Heather J Lee, Isabelle Nett, Hendrik Marks, Rachael Walker, Hendrik G Stunnenberg, Kathryn S Lilley and 4 more

Abstract read
In one paragraph

Article in Development (Cambridge, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 178 papers.

0numbers the graph read from it
0cells of the map it votes in
178citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

178 citing papers in PubMed.

  1. Review
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118 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Tüzer KalkanWellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Cambridge CB2 1QR, UK tk360@cam.ac.uk austin.smith@cscr.cam.ac.uk.
Nelly OlovaBabraham Institute, Cambridge CB22 3AT, UK.
Mila RoodeWellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Cambridge CB2 1QR, UK.
Carla MulasWellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Cambridge CB2 1QR, UK.
Heather J LeeBabraham Institute, Cambridge CB22 3AT, UK.
Isabelle NettWellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Cambridge CB2 1QR, UK.
Hendrik MarksRadboud University, Faculty of Science, Department of Molecular Biology, Radboud Institute for Molecular Life Sciences (RIMLS), Nijmegen 6500HB, The Netherlands.
Rachael WalkerWellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Cambridge CB2 1QR, UK.
Hendrik G StunnenbergRadboud University, Faculty of Science, Department of Molecular Biology, Radboud Institute for Molecular Life Sciences (RIMLS), Nijmegen 6500HB, The Netherlands.
Kathryn S LilleyDepartment of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK.
Jennifer NicholsWellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Cambridge CB2 1QR, UK.
Wolf ReikBabraham Institute, Cambridge CB22 3AT, UK.
Paul BertoneWellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Cambridge CB2 1QR, UK.
Austin SmithWellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Cambridge CB2 1QR, UK tk360@cam.ac.uk austin.smith@cscr.cam.ac.uk.ORCID 0000-0002-3029-4682

Funding

Biotechnology and Biological Sciences Research Council BB/K010867/1Biotechnology and Biological Sciences Research Council BB/M004023/1Medical Research Council G1100526Medical Research Council MC_PC_12009Wellcome TrustWellcome Trust 091484/Z/10/ZWellcome Trust 095645/Z/11/Z
6 · The paper itself

Abstract

Mouse embryonic stem (ES) cells are locked into self-renewal by shielding from inductive cues. Release from this ground state in minimal conditions offers a system for delineating developmental progression from naïve pluripotency. Here, we examine the initial transition process. The ES cell population behaves asynchronously. We therefore exploited a short-half-life

Indexed as

Cell TrackingAnimalsCell LineageCell Self RenewalDNA MethylationDown-RegulationEmbryo, MammalianEmbryonic Stem CellsGenes, ReporterGerm LayersKineticsMicePluripotent Stem CellsStem Cell TransplantationTranscription FactorsTranscription, GeneticTranscription FactorsEpiblastES cellsMethylomePluripotencyRex1Transcriptome

Identifiers

PMID28174249
PMCPMC5399622

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.