Evidence map›Paper›PMID 28174607›Full record

ArticleClinical epigenetics2017

Verena Sailer, Emily Eva Holmes, Heidrun Gevensleben, Diane Goltz, Freya Dröge, Alina Franzen, Jörn Dietrich, Glen Kristiansen, Friedrich Bootz, Andreas Schröck and 1 more

Open access · goldAbstract read
In one paragraph

Article in Clinical epigenetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. PITX1 plays essential functions in cancer.Frontiers in oncology · 2023
    Review
  3. Article
  4. Article
  5. Article
  6. The expression and methylation ofFrontiers in genetics · 2022
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Verena SailerDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY USA.
Emily Eva HolmesInstitute of Pathology, University Hospital Bonn, Bonn, Germany.
Heidrun GevenslebenInstitute of Pathology, University Hospital Bonn, Bonn, Germany.
Diane GoltzInstitute of Pathology, University Hospital Cologne, Cologne, Germany.
Freya DrögeDepartment of Otorhinolaryngology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Alina FranzenDepartment of Otolaryngology, Head and Neck Surgery, University Hospital Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany.
Jörn DietrichDepartment of Otolaryngology, Head and Neck Surgery, University Hospital Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany.
Glen KristiansenInstitute of Pathology, University Hospital Bonn, Bonn, Germany.
Friedrich BootzDepartment of Otolaryngology, Head and Neck Surgery, University Hospital Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany.
Andreas SchröckDepartment of Otolaryngology, Head and Neck Surgery, University Hospital Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany.
Dimo DietrichDepartment of Otolaryngology, Head and Neck Surgery, University Hospital Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany.
University Hospital Bonn · DEUniversity Hospital Cologne · DEUniversity of Duisburg-Essen · DEWeill Cornell Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMolecular biomarkers assisting risk-group assignment and subsequent treatment stratification are urgently needed for patients with squamous cell cancer of the head and neck region (HNSCC). Aberrant methylation is a frequent event in cancer and, therefore, a promising source for potential biomarkers. Here, the methylation status of the paired-like homeodomain transcription factor 3 (

methodsUsing a quantitative real-time PCR,

results

conclusions

Indexed as

DNA MethylationBiomarkers, TumorCarcinoma, Squamous CellCohort StudiesEpigenesis, GeneticFemaleGene Expression Regulation, NeoplasticHead and Neck NeoplasmsHomeodomain ProteinsHumansLymph NodesMaleMiddle AgedPapillomavirus InfectionsPrognosisSquamous Cell Carcinoma of Head and NeckBiomarkers, Tumorhomeobox protein PITX3Homeodomain ProteinsTranscription FactorsBiomarkerDNA methylationHead and neck squamous cell carcinomaHNSCCHPVPITX3Prognosis

Identifiers

PMID28174607
PMCPMC5290668
OpenAlexW2584020663

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.