Evidence map›Paper›PMID 28188129›Full record

ArticleBone & joint research2017

Enhancement of fracture healing in the rat, modulated by compounds that stimulate inducible nitric oxide synthase: Acceleration of fracture healing via inducible nitric oxide synthase.

R A Rajfer, A Kilic, A S Neviaser, L M Schulte, S M Hlaing, J Landeros, M G Ferrini, E Ebramzadeh, S-H Park

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone & joint research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
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  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Molecular pathogenesis of fracture nonunion.Journal of orthopaedic translation · 2018
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

R A RajferDepartment of Orthopaedic Surgery, George Washington University, Washington DC, USA.
A KilicDepartment of Orthopaedics, School of Medicine, Bahcesehir University, Istanbul, Turkey.
A S NeviaserDepartment of Orthopaedic Surgery, George Washington University, Washington DC, USA.
L M SchulteDepartment of Orthopaedic Surgery, George Washington University, Washington DC, USA.
S M HlaingDepartment of Health and Life Sciences, College of Science and Health, Charles Drew University of Medicine and Science, Los Angeles, California, USA.
J LanderosDepartment of Health and Life Sciences, College of Science and Health, Charles Drew University of Medicine and Science, Los Angeles, California, USA.
M G FerriniDepartment of Health and Life Sciences, College of Science and Health, Charles Drew University of Medicine and Science, Los Angeles, California, USA.
E EbramzadehDepartment of Orthopaedic Surgery, The J. Vernon Luck, Sr., M.D. Orthopaedic Research Center, Orthopaedic Institute for Children, University of California, Los Angeles, California, USA.
S-H ParkDepartment of Orthopaedic Surgery, The J. Vernon Luck, Sr., M.D. Orthopaedic Research Center, Orthopaedic Institute for Children, University of California, Los Angeles, California, USA SangHyunPark@mednet.ucla.edu.
Charles R. Drew University of Medicine and Science · USGeorge Washington University · USOrthopaedic Institute for Children · USBahçeşehir University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesWe investigated the effects on fracture healing of two up-regulators of inducible nitric oxide synthase (iNOS) in a rat model of an open femoral osteotomy: tadalafil, a phosphodiesterase inhibitor, and the recently reported nutraceutical, COMB-4 (consisting of L-citrulline, Paullinia cupana, ginger and muira puama), given orally for either 14 or 42 days. MATERIALS AND

methodsUnilateral femoral osteotomies were created in 58 male rats and fixed with an intramedullary compression nail. Rats were treated daily either with vehicle, tadalafil or COMB-4. Biomechanical testing of the healed fracture was performed on day 42. The volume, mineral content and bone density of the callus were measured by quantitative CT on days 14 and 42. Expression of iNOS was measured by immunohistochemistry.

resultsWhen compared with the control group, the COMB-4 group exhibited 46% higher maximum strength (

conclusionThis study demonstrates an enhancement in fracture healing by an oral natural product known to augment iNOS expression.

Indexed as

BiomechanicalFractureInducible nitric oxide synthaseNutraceuticalTadalafil

Identifiers

PMID28188129
PMCPMC5331177
OpenAlexW2587522463

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.