ArticleThe Journal of biological chemistry2017
Hydrogen sulfide inhibits high glucose-induced NADPH oxidase 4 expression and matrix increase by recruiting inducible nitric oxide synthase in kidney proximal tubular epithelial cells.
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Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
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Who cites it
32 citing papers in PubMed, 51 citations in OpenAlex.
- The Role of Ferroptosis in Diabetes Pathogenesis: Therapeutic Implications of Hydrogen Sulfide and Its Reactive Metabolites.Antioxidants (Basel, Switzerland) · 2026Review
- Hydrogen sulfide promotes lateral root formation in peach through persulfidation of SnRK1α kinase.Plant biotechnology journal · 2025Article
- Gut Microbiota and Their Metabolites: The Hidden Driver of Diabetic Nephropathy? Unveiling Gut Microbe's Role in DN.Journal of diabetes · 2025Review
- The CLCA1/TMEM16A/Cl- current axis associates with H2S deficiency in diabetic kidney injury.JCI insight · 2025Article
- High glucose couples DJ-1 with PTEN to activate PDGFRβ for renal proximal tubular cell injury.PloS one · 2025Article
- Protective Role of HDiabetes, metabolic syndrome and obesity : targets and therapy · 2025Review
- Xanthine oxidoreductase inhibition ameliorates high glucose-induced glomerular endothelial injury by activating AMPK through the purine salvage pathway.Scientific reports · 2024Article
- Endogenous adenine mediates kidney injury in diabetic models and predicts diabetic kidney disease in patients.The Journal of clinical investigation · 2023Article
- Molecular Basic of Pharmacotherapy of Cytokine Imbalance as a Component of Intervertebral Disc Degeneration Treatment.International journal of molecular sciences · 2023Review
- Therapeutic role of growth factors in treating diabetic wound.World journal of diabetes · 2023Review
- The roles of hydrogen sulfide in renal physiology and disease states.Renal failure · 2022Review
- Effects of transforming growth factor beta-activated kinase 1 (TAK1) on apoptosis of HK-2 cells in the high glucose environment.Bioengineered · 2022Article
- Protective effect of hydrogen sulfide on the kidney (Review).Molecular medicine reports · 2021Review
- Chloride channel accessory 1 integrates chloride channel activity and mTORC1 in aging-related kidney injury.Aging cell · 2021Article
- Proximal tubular epithelial insulin receptor mediates high-fat diet-induced kidney injury.JCI insight · 2021Article
- Hydrogen Sulfide and the Kidney.Advances in experimental medicine and biology · 2021Article
- Hydrogen Sulfide and the Immune System.Advances in experimental medicine and biology · 2021Article
- Interaction among Hydrogen Sulfide and Other Gasotransmitters in Mammalian Physiology and Pathophysiology.Advances in experimental medicine and biology · 2021Review
- Hydrogen Sulfide and Carnosine: Modulation of Oxidative Stress and Inflammation in Kidney and Brain Axis.Antioxidants (Basel, Switzerland) · 2020Review
- Critical Role for AMPK in Metabolic Disease-Induced Chronic Kidney Disease.International journal of molecular sciences · 2020Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Hak Joo LeeFrom the University of Texas Health Science Center, San Antonio, Texas 78229-3900 and.
Doug Yoon LeeFrom the University of Texas Health Science Center, San Antonio, Texas 78229-3900 and.
Meenalakshmi M MariappanFrom the University of Texas Health Science Center, San Antonio, Texas 78229-3900 and.
Denis FeliersFrom the University of Texas Health Science Center, San Antonio, Texas 78229-3900 and.
Goutam Ghosh-ChoudhuryFrom the University of Texas Health Science Center, San Antonio, Texas 78229-3900 and.
Hanna E AbboudFrom the University of Texas Health Science Center, San Antonio, Texas 78229-3900 and.
Yves GorinFrom the University of Texas Health Science Center, San Antonio, Texas 78229-3900 and.
Balakuntalam S KasinathFrom the University of Texas Health Science Center, San Antonio, Texas 78229-3900 and Kasinath@uthscsa.edu.
South Texas Veterans Health Care System · USThe University of Texas Health Science Center at San Antonio · US
Funding
TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Lei Zheng · 1991 to 2026
$59.1MInstitute for Integration of Medicine & Science: A Partnership to Improve HealthUL1TR001120 · NCATS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CLARK, ROBERT A, HARGREAVES, KENNETH M · 2013 to 2017
$16.5MMechanism of Renal Cell Injury in DiabetesR01DK050190 · NIDDK · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI GHOSH CHOUDHURY, GOUTAM · 2004 to 2013
$2.3MINFLAMMATORY MEDIATORS AND GLOMERULAR CELLS IN CULTURER37DK033665 · NIDDK · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI ABBOUD, HANNA E · 1998 to 2007
$2.1MMechanism of eNOS Uncoupling in the Renal MicrovasculatureR01DK079996 · NIDDK · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI GORIN, YVES CLAUDE · 2010 to 2014
$1.5MNovel mechanisms of diabetic nephropathyR01DK077295 · NIDDK · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI KASINATH, BALAKUNTALAM S · 2007 to 2011
$1.3MTubular epithelial cell injuryR01DK033665 · NIDDK · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI GORIN, YVES CLAUDE · 1986 to 2015
$1.3MTYROSINE PHOSPHATASES IN GLOMERULAR CELL INJURYR29DK050190 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT · PI GHOSH CHOUDHURY, GOUTAM · 1996 to 2000
$101kMechanisms of Renal Cell InjuryI01BX000926 · VA · SOUTH TEXAS VETERANS HEALTH CARE SYSTEM · PI GHOSH CHOUDHURY, GOUTAM, SHARMA, KUMAR · 2011 to 2024
–New Insights in Mechanisms of Renal InjuryI01BX001340 · VA · SOUTH TEXAS VETERANS HEALTH CARE SYSTEM · PI Kumar Sharma · 2012 to 2026
–BLRD VA I01 BX000926BLRD VA I01 BX001340BLRD VA IK6 BX003611NCATS NIH HHS UL1 TR001120NCI NIH HHS P30 CA054174NIDDK NIH HHS R01 DK033665NIDDK NIH HHS R01 DK050190NIDDK NIH HHS R01 DK077295NIDDK NIH HHS R01 DK079996NIDDK NIH HHS R29 DK050190NIDDK NIH HHS R37 DK033665
Abstract
High-glucose increases NADPH oxidase 4 (NOX4) expression, reactive oxygen species generation, and matrix protein synthesis by inhibiting AMP-activated protein kinase (AMPK) in renal cells. Because hydrogen sulfide (H
Indexed as
AmidinesAMP-Activated Protein KinasesAnimalsBenzylaminesDiabetic NephropathiesEpithelial CellsExtracellular Matrix ProteinsGene Expression Regulation, EnzymologicGlucoseHydrogen SulfideKidney Tubules, ProximalMiceNADPH Oxidase 4NADPH OxidasesNitric OxideNitric Oxide Synthase Type IIAmidinesAMP-Activated Protein KinasesBenzylaminesExtracellular Matrix ProteinsGlucoseHydrogen SulfideN-(3-(aminomethyl)benzyl)acetamidineNADPH Oxidase 4NADPH OxidasesNitric OxideNitric Oxide Synthase Type IINos2 protein, mouseNox4 protein, mouseAMP-activated kinase (AMPK)diabetic nephropathylamininoxidative stressreactive oxygen species (ROS)
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.