Evidence map›Paper›PMID 28193840›Full record

ArticleThe Journal of biological chemistry2017

Co-chaperone Hsp70/Hsp90-organizing protein (Hop) is required for transposon silencing and Piwi-interacting RNA (piRNA) biogenesis.

Joseph A Karam, Rasesh Y Parikh, Dhananjaya Nayak, David Rosenkranz, Vamsi K Gangaraju

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
11.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 39 citations in OpenAlex.

  1. Review
  2. Extracellular ssDNA fromInternational journal of molecular sciences · 2026
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  15. Dissecting the Molecular Function ofFrontiers in genetics · 2020
    Article
  16. The Hsp70 chaperone is a major player in stress-induced transposable element activation.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Joseph A KaramFrom the Department of Biochemistry and Molecular Biology and Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina 29425 and.
Rasesh Y ParikhFrom the Department of Biochemistry and Molecular Biology and Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina 29425 and.
Dhananjaya NayakFrom the Department of Biochemistry and Molecular Biology and Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina 29425 and.
David Rosenkranzthe Institute of Organismic and Molecular Evolutionary Biology, Johannes Gutenberg-Universität Mainz, 55122 Mainz, Germany.
Vamsi K GangarajuFrom the Department of Biochemistry and Molecular Biology and Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina 29425 and gangaraj@musc.edu.
Medical University of South Carolina · USMUSC Hollings Cancer Center · USJohannes Gutenberg University Mainz · DE

Funding

Translational Science Laboratory Shared ResourceP30CA138313 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Jian Ouyang · 2009 to 2026
$42.7M
Novel Role for Piwi/piRNA pathway in developmental robustnessR00ES021736 · NIEHS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI GANGARAJU, VAMSI · 2014 to 2016
$747k
NCI NIH HHS P30 CA138313NIEHS NIH HHS R00 ES021736
6 · The paper itself

Abstract

Piwi-interacting RNAs (piRNAs) are 26-30-nucleotide germ line-specific small non-coding RNAs that have evolutionarily conserved function in mobile genetic element (transposons) silencing and maintenance of genome integrity.

Indexed as

DNA Transposable ElementsGene SilencingAnimalsAnimals, Genetically ModifiedArgonaute ProteinsDNA DamageDrosophila melanogasterDrosophila ProteinsFemaleGenomic InstabilityGerm CellsJanus KinasesOvaryRNA, Small InterferingTranscription FactorsArgonaute ProteinsDNA Transposable ElementsDrosophila Proteinshop protein, DrosophilaJanus Kinasespiwi protein, DrosophilaRNA, Small InterferingTranscription FactorsDNA damage responseheat shock protein 90 (Hsp90)heat shock protein (HSP)RNARNA interference (RNAi)

Identifiers

PMID28193840
PMCPMC5391737
OpenAlexW2588196190

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.