Trial reportProceedings of the National Academy of Sciences of the United States of America2017
Systems analysis of protective immune responses to RTS,S malaria vaccination in humans.
Open access · bronzeAbstract readClinical Trial
In one paragraph
Trial report in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 182 papers.
0numbers the graph read from it
0cells of the map it votes in
182citing papers in PubMed
15.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
182 citing papers in PubMed, 302 citations in OpenAlex.
- Shared clinical and immunologic features of mRNA vaccines: preliminary results from a comparative clinical study.Frontiers in immunology · 2025Trial
- Innate immune activation restricts priming and protective efficacy of the radiation-attenuated PfSPZ malaria vaccine.JCI insight · 2024Trial
- Co-regulation of innate and adaptive immune responses induced by ID93+GLA-SE vaccination in humans.Frontiers in immunology · 2024Trial
- An innate immune signature induced by AS01- or AS03-adjuvanted vaccines predicts the antibody response magnitude and quality consistently over time.Frontiers in immunology · 2024Trial
- Sex and prior exposure jointly shape innate immune responses to a live herpesvirus vaccine.eLife · 2023Trial
- The Anti-Circumsporozoite Antibody Response of Children to Seasonal Vaccination With the RTS,S/AS01E Malaria Vaccine.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Trial
- Randomized clinical trial to assess the protective efficacy of a Plasmodium vivax CS synthetic vaccine.Nature communications · 2022Trial
- Systems analysis of immune responses to attenuated P. falciparum malaria sporozoite vaccination reveals excessive inflammatory signatures correlating with impaired immunity.PLoS pathogens · 2022Trial
- A Randomized Placebo-Controlled Efficacy Study of a Prime Boost Therapeutic Vaccination Strategy in HIV-1-Infected Individuals: VRI02 ANRS 149 LIGHT Phase II Trial.Journal of virology · 2021Trial
- Early Pro-Inflammatory Signal and T-Cell Activation Associate With Vaccine-Induced Anti-Vaccinia Protective Neutralizing Antibodies.Frontiers in immunology · 2021Trial
- A Systems Vaccinology Approach Reveals the Mechanisms of Immunogenic Responses to Hantavax Vaccination in Humans.Scientific reports · 2019Trial
- Inflammation induced by influenza virus impairs human innate immune control of pneumococcus.Nature immunology · 2018Trial
- Adjuvant-Associated Peripheral Blood mRNA Profiles and Kinetics Induced by the Adjuvanted Recombinant Protein Candidate Tuberculosis Vaccine M72/AS01 in Bacillus Calmette-Guérin-Vaccinated Adults.Frontiers in immunology · 2018Trial
- Rescuing age-associated vaccine hyporesponsiveness in murine and nonhuman primate models with an immunostimulatory vaccine adjuvant.Human vaccines & immunotherapeutics · 2026Article
- Host cell traversal by Plasmodium parasites drives sterilizing T cell-mediated immunity following immunization.Nature microbiology · 2026Article
- Review
- Unconventional functions of natural killer cells in homeostasis and disease.Journal of immunology (Baltimore, Md. : 1950) · 2026Review
- Correlates of protection against African swine fever virus identified by a systems immunology approach.eLife · 2026Article
- Accelerating Innovation: Advancing Opportunities in HIV Vaccine Development.Current HIV research · 2026Review
- CD4 T cell phenotype after AS01-adjuvanted immunization is shaped by prior antigen or pathogen exposure.Frontiers in immunology · 2026Article
122 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 8 institutions in 3 countries.
Dmitri KazminEmory Vaccine Center, Emory University, Atlanta, GA 30329.
Helder I NakayaSchool of Pharmaceutical Sciences, University of Sao Paulo, São Paulo 05508, Brazil.
Eva K LeeSchool of Industrial and Systems Engineering, Georgia Institute of Technology, Atlanta, GA 30332.
Matthew J JohnsonCenter for Genome Engineering, University of Minnesota, Minneapolis, MN 55108.
Robbert van der MostGSK Vaccines, Rixensart 1330, Belgium.
Robert A van den BergGSK Vaccines, Rockville, MD 20850.
W Ripley BallouGSK Vaccines, Rockville, MD 20850.
Erik JongertGSK Vaccines, Rixensart 1330, Belgium.
Ulrike Wille-ReeceProgram for Appropriate Technology in Health-Malaria Vaccine Initiative, Washington, DC 20001.
Christian OckenhouseProgram for Appropriate Technology in Health-Malaria Vaccine Initiative, Washington, DC 20001.
Alan AderemCenter for Infectious Disease Research, Seattle, WA 98109.
Daniel E ZakCenter for Infectious Disease Research, Seattle, WA 98109.
Jerald SadoffCrucell, Leiden 2333, The Netherlands.
Jenny HendriksCrucell, Leiden 2333, The Netherlands.
Jens WrammertEmory Vaccine Center, Emory University, Atlanta, GA 30329.
Rafi AhmedEmory Vaccine Center, Emory University, Atlanta, GA 30329; bpulend@emory.edu rahmed@emory.edu.
Bali PulendranEmory Vaccine Center, Emory University, Atlanta, GA 30329; bpulend@emory.edu rahmed@emory.edu.
Emory University · USCenter for Infectious Disease Research · USGlaxoSmithKline (Belgium) · BEGlaxoSmithKline (United States) · USProgram for Appropriate Technology in Health · USGeorgia Institute of Technology · USUniversidade de São Paulo · BRUniversity of Minnesota · US
Funding
Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0MVACCINE INDUCED IMMUNITY IN THE YOUNG AND AGEDU19AI057266 · NIAID · EMORY UNIVERSITY · PI Rafi Ahmed · 2003 to 2026
$81.7MSystems Biological Analysis of Innate and Adaptive Responses to VaccinationU19AI090023 · NIAID · EMORY UNIVERSITY · PI AHMED, RAFI, LI, SHUZHAO · 2010 to 2021
$45.0MUnderstanding the Role of Mucosal Antigen Presenting Cells in Regulating Immune ResponseR37AI048638 · NIAID · STANFORD UNIVERSITY · PI PULENDRAN, BALI · 2009 to 2018
$4.0MEmory R38 Research Training ProgramR38AI140299 · NIAID · EMORY UNIVERSITY · PI OFOTOKUN, IGHOVWERHA, ROUPHAEL, NADINE GEORGES · 2018 to 2021
$1.4MNIAID NIH HHS R37 AI048638NIAID NIH HHS R38 AI140299NIAID NIH HHS U19 AI057266NIAID NIH HHS U19 AI090023NIH HHS P51 OD011132
Abstract
RTS,S is an advanced malaria vaccine candidate and confers significant protection against
Indexed as
Adaptive ImmunityAdenoviridaeAntibodies, ProtozoanB-LymphocytesCD4-Positive T-LymphocytesDendritic CellsGene Expression ProfilingGene Expression RegulationGenetic VectorsHumansImmunity, InnateImmunization, SecondaryImmunogenicity, VaccineKiller Cells, NaturalMalaria, FalciparumMalaria VaccinesAntibodies, Protozoancircumsporozoite protein, ProtozoanMalaria VaccinesProtozoan ProteinsRTS,S-AS01 vaccineVaccines, Syntheticimmunemalariasystems biologysystems vaccinologyvaccine
Identifiers
What Socratic holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.